Model calculations of the effects of wide-band inhibitors in the dorsal cochlear nucleus.

Journal Article (Journal Article)

In two previous papers [Reed and Blum, J. Acoust. Soc. Am. 97, 425-438 (1995), Blum et al., J. Acoust. Soc. Am. 98, 181-191 (1995)] a computational model for signal processing in the dorsal cochlear nucleus (DCN) was developed. In those modelling studies, stellate cells inhibited only type II cells. In this study, the effect of including wide-band inhibitory (WBI) connections from stellate cells to type IV cells, as proposed by Nelken and Young [J. Neurophysiol. 71, 2446-2462 (1994)], is examined. Inclusion of the WBI connections improves the fit to the experimental pure tone response maps for both the "standard" and "non-standard" cells examined by Spirou and Young [J. Neurophysiol. 66, 1750-1768 (1991)]. Thus, these modelling studies support the hypothesis of Nelken and Young [J. Neurophysiol. 71, 2446-2462 (1994)]. The degree of improvement is greatest for cells with prominent upper inhibitory sidebands. The qualitative features of the pure tone response map and the theoretical model allow one to deduce the probable frequency bias of the type II to type IV and stellate to type IV connections.

Full Text

Duke Authors

Cited Authors

  • Reed, MC; Blum, JJ

Published Date

  • October 1997

Published In

Volume / Issue

  • 102 / 4

Start / End Page

  • 2238 - 2244

PubMed ID

  • 9348681

Electronic International Standard Serial Number (EISSN)

  • 1520-8524

International Standard Serial Number (ISSN)

  • 0001-4966

Digital Object Identifier (DOI)

  • 10.1121/1.419595


  • eng