Theoretical analysis of lipid transport in sciatic nerve.

Published

Journal Article

We modify our previous mathematical model of axonal transport to analyze data on the fast transport of lipids in rat sciatic nerve given in Toews et al. (J. Neurochem. 40, 555-562 (1983)). The theoretical model accounts well for the shapes of the profiles of phosphatidylcholine, phosphatidylethanolamine, cholesterol and diphosphatidylglycerol. The parameters obtained support the qualitative conclusions of Toews et al. and provide quantitative estimates of the underlying processes, e.g., rates of vesicle and mitochondria translocation, rate constants for association and dissociation between vesicles, kinesin and microtubules, rates of deposition and rates of loss of each class of lipid from the nerve by leakage or via removal by the retrograde transport system. The analysis suggests that two classes of vesicles moving at different speeds may be involved in the transport of phosphatidylcholine and phosphatidylethanolamine.

Full Text

Duke Authors

Cited Authors

  • Blum, JJ; Carr, DD; Reed, MC

Published Date

  • May 1992

Published In

Volume / Issue

  • 1125 / 3

Start / End Page

  • 313 - 320

PubMed ID

  • 1596520

Pubmed Central ID

  • 1596520

Electronic International Standard Serial Number (EISSN)

  • 1878-2434

International Standard Serial Number (ISSN)

  • 0006-3002

Digital Object Identifier (DOI)

  • 10.1016/0005-2760(92)90061-y

Language

  • eng