Theoretical analysis of lipid transport in sciatic nerve.
Journal Article (Journal Article)
We modify our previous mathematical model of axonal transport to analyze data on the fast transport of lipids in rat sciatic nerve given in Toews et al. (J. Neurochem. 40, 555-562 (1983)). The theoretical model accounts well for the shapes of the profiles of phosphatidylcholine, phosphatidylethanolamine, cholesterol and diphosphatidylglycerol. The parameters obtained support the qualitative conclusions of Toews et al. and provide quantitative estimates of the underlying processes, e.g., rates of vesicle and mitochondria translocation, rate constants for association and dissociation between vesicles, kinesin and microtubules, rates of deposition and rates of loss of each class of lipid from the nerve by leakage or via removal by the retrograde transport system. The analysis suggests that two classes of vesicles moving at different speeds may be involved in the transport of phosphatidylcholine and phosphatidylethanolamine.
Full Text
Duke Authors
Cited Authors
- Blum, JJ; Carr, DD; Reed, MC
Published Date
- May 1992
Published In
Volume / Issue
- 1125 / 3
Start / End Page
- 313 - 320
PubMed ID
- 1596520
Electronic International Standard Serial Number (EISSN)
- 1878-2434
International Standard Serial Number (ISSN)
- 0006-3002
Digital Object Identifier (DOI)
- 10.1016/0005-2760(92)90061-y
Language
- eng