A model for slow axonal transport and its application to neurofilamentous neuropathies.

Journal Article (Journal Article)

A model for slow axonal transport is developed in which the essential features are reversible binding of cytoskeletal elements and of soluble cytosolic proteins to each other and to motile elements such as actin microfilaments. Computer simulation of the equations of the model demonstrate that the model can account for many of the features of the SCa and SCb waves observed in pulse experiments. The model also provides a unified explanation for the increase and decrease of neurofilament transport rates observed in various toxicant-induced neuropathies.

Full Text

Duke Authors

Cited Authors

  • Blum, JJ; Reed, MC

Published Date

  • January 1989

Published In

Volume / Issue

  • 12 / 1

Start / End Page

  • 53 - 65

PubMed ID

  • 2468419

Electronic International Standard Serial Number (EISSN)

  • 1097-0169

International Standard Serial Number (ISSN)

  • 0886-1544

Digital Object Identifier (DOI)

  • 10.1002/cm.970120107


  • eng