The transport of organelles in axons

Published

Journal Article

The fast anterograde and retrograde transport systems in axons convey organelles from the soma, where synthesis occurs, to the synaptic region and back. Studies of label incorporation into newly synthesized organelles show that they move along the axon with profiles resembling traveling waves. The underlying mechanism appears to be that cross-bridging "engines" attach to the organelles and this complex then attaches by the engines to the surface of microtubules, resulting in translocation of the organelles. A model incorporating this mechanism predicts traveling-wave-like profiles of labeled organelles and can serve to link mechanistic information with fast transport measurements in intact axons. Analysis of the simplest case provides insight into the factors determining the speed and shape of the wavelike profile. © 1988.

Full Text

Duke Authors

Cited Authors

  • Blum, JJ; Reed, MC

Published Date

  • January 1, 1988

Published In

Volume / Issue

  • 90 / 1-2

Start / End Page

  • 233 - 245

International Standard Serial Number (ISSN)

  • 0025-5564

Digital Object Identifier (DOI)

  • 10.1016/0025-5564(88)90068-5

Citation Source

  • Scopus