Theoretical analysis of radioactivity profiles during fast axonal transport: effects of deposition and turnover.

Journal Article (Journal Article)

In a preceding study [Blum, J.J., and Reed, M.C. (1985): Cell Motil. 5:507-527], factors responsible for the shape and velocity of the leading edge of the radiolabeled organelle profile were analyzed, but processes that might influence the shape of the plateau-like region behind the advancing wave were ignored. It is now shown that deposition of material from the fast transport system into membrane-associated structures, degradation of such deposited material and its return to the soma by the retrograde transport system, or leakage of radiolabeled material from the axon can account for the shape of the plateau. Furthermore, these processes are compatible with the maintenance of such structural inhomogeneities as the nodes of Ranvier.

Full Text

Duke Authors

Cited Authors

  • Reed, MC; Blum, JJ

Published Date

  • January 1, 1986

Published In

Volume / Issue

  • 6 / 6

Start / End Page

  • 620 - 627

PubMed ID

  • 2433057

Electronic International Standard Serial Number (EISSN)

  • 1097-0169

International Standard Serial Number (ISSN)

  • 0886-1544

Digital Object Identifier (DOI)

  • 10.1002/cm.970060610


  • eng