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Follicular lymphoma with prominent Dutcher body formation: a pathologic study of 3 cases in comparison with nodal or splenic lymphoplasmacytic lymphoma and marginal zone lymphoma.

Publication ,  Journal Article
Wang, E; Stoecker, M; Burchette, J; Rehder, C
Published in: Hum Pathol
November 2012

Dutcher bodies have been described in lymphoid neoplasms with plasmacytic differentiation, including plasma cell myeloma, lymphoplasmacytic lymphoma, and marginal zone lymphoma. We report a pathologic study of 3 cases of follicular lymphoma with extensive Dutcher body formation in comparison with lymphoplasmacytic lymphoma and marginal zone lymphoma. Of 3 cases, 1 showed a follicular growth pattern, whereas the other 2 cases demonstrated only a vague nodular appearance highlighted by immunohistochemical analysis. Cells containing Dutcher bodies were counted at 25, 90, or 110 per high-power field in each case, respectively. In 2 cases, cells with Dutcher bodies were clustered in an intrafollicular distribution, a possible histopathologic clue for follicular lymphoma. Immunoglobulin M κ was identified as the component of Dutcher bodies in all 3 cases, implying a possible molecular basis for the formation of Dutcher bodies in B-cell lymphomas. All 3 cases had cytogenetic changes supporting the diagnosis of follicular lymphoma, including dual rearrangement of BCL2 and BCL6, rearrangement of BCL2 with trisomy 3 (BCL6), and isolated BCL6 rearrangement. We emphasize immunohistochemical analyses with anti-κ/λ and anti-immunoglobulin heavy-chain isotypes to characterize Dutcher bodies and document clonality in addition to the routine lymphoma workup and indicated cytogenetic studies in B-cell lymphomas with prominent Dutcher bodies.

Duke Scholars

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

November 2012

Volume

43

Issue

11

Start / End Page

2001 / 2011

Location

United States

Related Subject Headings

  • Waldenstrom Macroglobulinemia
  • Splenic Neoplasms
  • Pathology
  • Middle Aged
  • Male
  • Lymphoma, Follicular
  • Lymphoma, B-Cell, Marginal Zone
  • Lymph Nodes
  • Intranuclear Inclusion Bodies
  • In Situ Hybridization, Fluorescence
 

Citation

APA
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ICMJE
MLA
NLM
Wang, E., Stoecker, M., Burchette, J., & Rehder, C. (2012). Follicular lymphoma with prominent Dutcher body formation: a pathologic study of 3 cases in comparison with nodal or splenic lymphoplasmacytic lymphoma and marginal zone lymphoma. Hum Pathol, 43(11), 2001–2011. https://doi.org/10.1016/j.humpath.2012.02.009
Wang, Endi, Maggie Stoecker, James Burchette, and Catherine Rehder. “Follicular lymphoma with prominent Dutcher body formation: a pathologic study of 3 cases in comparison with nodal or splenic lymphoplasmacytic lymphoma and marginal zone lymphoma.Hum Pathol 43, no. 11 (November 2012): 2001–11. https://doi.org/10.1016/j.humpath.2012.02.009.
Wang, Endi, et al. “Follicular lymphoma with prominent Dutcher body formation: a pathologic study of 3 cases in comparison with nodal or splenic lymphoplasmacytic lymphoma and marginal zone lymphoma.Hum Pathol, vol. 43, no. 11, Nov. 2012, pp. 2001–11. Pubmed, doi:10.1016/j.humpath.2012.02.009.
Journal cover image

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

November 2012

Volume

43

Issue

11

Start / End Page

2001 / 2011

Location

United States

Related Subject Headings

  • Waldenstrom Macroglobulinemia
  • Splenic Neoplasms
  • Pathology
  • Middle Aged
  • Male
  • Lymphoma, Follicular
  • Lymphoma, B-Cell, Marginal Zone
  • Lymph Nodes
  • Intranuclear Inclusion Bodies
  • In Situ Hybridization, Fluorescence