Directed cell migration on fibronectin gradients: effect of gradient slope.
Publication
, Journal Article
Smith, JT; Elkin, JT; Reichert, WM
Published in: Experimental cell research
August 2006
The migration of human microvascular endothelial cells (hMEC) was measured on a range of fibronectin gradient slopes. hMEC drift speed increased with increasing gradient slope with no concurrent change in cellular persistence time or random cell speed. The frequency of discrete cellular motion in the gradient direction increased with gradient slope. Morphological polarization of cells on the gradients is also characterized and correlated with cellular drift speed. These experiments present the first demonstration of cellular response to changing haptotactic gradient slope using an in vitro system for the quantitative study of cell migration.
Duke Scholars
Published In
Experimental cell research
DOI
EISSN
1090-2422
ISSN
0014-4827
Publication Date
August 2006
Volume
312
Issue
13
Start / End Page
2424 / 2432
Related Subject Headings
- Humans
- Fibronectins
- Endothelial Cells
- Dose-Response Relationship, Drug
- Cells, Cultured
- Cell Polarity
- Cell Movement
- Biochemistry & Molecular Biology
- Actins
- 3101 Biochemistry and cell biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Smith, J. T., Elkin, J. T., & Reichert, W. M. (2006). Directed cell migration on fibronectin gradients: effect of gradient slope. Experimental Cell Research, 312(13), 2424–2432. https://doi.org/10.1016/j.yexcr.2006.04.005
Smith, Jason T., James T. Elkin, and W Monty Reichert. “Directed cell migration on fibronectin gradients: effect of gradient slope.” Experimental Cell Research 312, no. 13 (August 2006): 2424–32. https://doi.org/10.1016/j.yexcr.2006.04.005.
Smith JT, Elkin JT, Reichert WM. Directed cell migration on fibronectin gradients: effect of gradient slope. Experimental cell research. 2006 Aug;312(13):2424–32.
Smith, Jason T., et al. “Directed cell migration on fibronectin gradients: effect of gradient slope.” Experimental Cell Research, vol. 312, no. 13, Aug. 2006, pp. 2424–32. Epmc, doi:10.1016/j.yexcr.2006.04.005.
Smith JT, Elkin JT, Reichert WM. Directed cell migration on fibronectin gradients: effect of gradient slope. Experimental cell research. 2006 Aug;312(13):2424–2432.
Published In
Experimental cell research
DOI
EISSN
1090-2422
ISSN
0014-4827
Publication Date
August 2006
Volume
312
Issue
13
Start / End Page
2424 / 2432
Related Subject Headings
- Humans
- Fibronectins
- Endothelial Cells
- Dose-Response Relationship, Drug
- Cells, Cultured
- Cell Polarity
- Cell Movement
- Biochemistry & Molecular Biology
- Actins
- 3101 Biochemistry and cell biology