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Directed cell migration on fibronectin gradients: effect of gradient slope.

Publication ,  Journal Article
Smith, JT; Elkin, JT; Reichert, WM
Published in: Experimental cell research
August 2006

The migration of human microvascular endothelial cells (hMEC) was measured on a range of fibronectin gradient slopes. hMEC drift speed increased with increasing gradient slope with no concurrent change in cellular persistence time or random cell speed. The frequency of discrete cellular motion in the gradient direction increased with gradient slope. Morphological polarization of cells on the gradients is also characterized and correlated with cellular drift speed. These experiments present the first demonstration of cellular response to changing haptotactic gradient slope using an in vitro system for the quantitative study of cell migration.

Duke Scholars

Published In

Experimental cell research

DOI

EISSN

1090-2422

ISSN

0014-4827

Publication Date

August 2006

Volume

312

Issue

13

Start / End Page

2424 / 2432

Related Subject Headings

  • Humans
  • Fibronectins
  • Endothelial Cells
  • Dose-Response Relationship, Drug
  • Cells, Cultured
  • Cell Polarity
  • Cell Movement
  • Biochemistry & Molecular Biology
  • Actins
  • 3101 Biochemistry and cell biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Smith, J. T., Elkin, J. T., & Reichert, W. M. (2006). Directed cell migration on fibronectin gradients: effect of gradient slope. Experimental Cell Research, 312(13), 2424–2432. https://doi.org/10.1016/j.yexcr.2006.04.005
Smith, Jason T., James T. Elkin, and W Monty Reichert. “Directed cell migration on fibronectin gradients: effect of gradient slope.Experimental Cell Research 312, no. 13 (August 2006): 2424–32. https://doi.org/10.1016/j.yexcr.2006.04.005.
Smith JT, Elkin JT, Reichert WM. Directed cell migration on fibronectin gradients: effect of gradient slope. Experimental cell research. 2006 Aug;312(13):2424–32.
Smith, Jason T., et al. “Directed cell migration on fibronectin gradients: effect of gradient slope.Experimental Cell Research, vol. 312, no. 13, Aug. 2006, pp. 2424–32. Epmc, doi:10.1016/j.yexcr.2006.04.005.
Smith JT, Elkin JT, Reichert WM. Directed cell migration on fibronectin gradients: effect of gradient slope. Experimental cell research. 2006 Aug;312(13):2424–2432.
Journal cover image

Published In

Experimental cell research

DOI

EISSN

1090-2422

ISSN

0014-4827

Publication Date

August 2006

Volume

312

Issue

13

Start / End Page

2424 / 2432

Related Subject Headings

  • Humans
  • Fibronectins
  • Endothelial Cells
  • Dose-Response Relationship, Drug
  • Cells, Cultured
  • Cell Polarity
  • Cell Movement
  • Biochemistry & Molecular Biology
  • Actins
  • 3101 Biochemistry and cell biology