Atomic force and total internal reflection fluorescence microscopy for the study of force transmission in endothelial cells
Publication
, Journal Article
Mathur, A; Reichert, W; Truskey, G
Published in: Annals of Biomedical Engineering
December 1, 2000
Atomic force microscopy (AFM) and total internal reflection fluorescence microscopy (TIRFM) were configured to examine the transmission of force applied from the apical cell membrane to the basal cell membrane of HUVECs. The precise localized mechanical perturbations, resulted in a global rearrangement of focal contacts at the basal membrane. The apical cell surface displayed a range of elastic moduli. Although the response remained global whether the region was soft or stiff, force application over the nuclear region appeared to produce a more consistent change in contact area, while the contact area responded variably to the force on the edge of the cell.
Duke Scholars
Published In
Annals of Biomedical Engineering
ISSN
0090-6964
Publication Date
December 1, 2000
Volume
28
Issue
SUPPL. 1
Related Subject Headings
- Biomedical Engineering
- 11 Medical and Health Sciences
- 09 Engineering
Citation
APA
Chicago
ICMJE
MLA
NLM
Mathur, A., Reichert, W., & Truskey, G. (2000). Atomic force and total internal reflection fluorescence microscopy for the study of force transmission in endothelial cells. Annals of Biomedical Engineering, 28(SUPPL. 1).
Mathur, A., W. Reichert, and G. Truskey. “Atomic force and total internal reflection fluorescence microscopy for the study of force transmission in endothelial cells.” Annals of Biomedical Engineering 28, no. SUPPL. 1 (December 1, 2000).
Mathur A, Reichert W, Truskey G. Atomic force and total internal reflection fluorescence microscopy for the study of force transmission in endothelial cells. Annals of Biomedical Engineering. 2000 Dec 1;28(SUPPL. 1).
Mathur, A., et al. “Atomic force and total internal reflection fluorescence microscopy for the study of force transmission in endothelial cells.” Annals of Biomedical Engineering, vol. 28, no. SUPPL. 1, Dec. 2000.
Mathur A, Reichert W, Truskey G. Atomic force and total internal reflection fluorescence microscopy for the study of force transmission in endothelial cells. Annals of Biomedical Engineering. 2000 Dec 1;28(SUPPL. 1).
Published In
Annals of Biomedical Engineering
ISSN
0090-6964
Publication Date
December 1, 2000
Volume
28
Issue
SUPPL. 1
Related Subject Headings
- Biomedical Engineering
- 11 Medical and Health Sciences
- 09 Engineering