Thrombogenesis: effect of molecular motions, surface order, and hydrophobicity of the polymer interface.

The effect and interrelationship between primary and secondary molecular motions, morphological order/disorder, and associated water on thrombogenesis are elucidated using an amorphous hydrophobic polymer of poly[trifluoroethoxy) ( fluoroalkoxy ) phosphazene ], a semicrystalline triblock copolymer of poly[(gamma-benzyl-L-glutamate) (acrylonitrile/butadiene) (gamma-benzyl-L-glutamate)] and a surface cross-linked hydrophilic/hydrophobic(core)/hydrophilic triblock copolymer of poly[(hydroxy propyl glutamine) (gamma-benzyl-L-glutamate) (hydroxy propyl glutamine)]. The thrombogenic response of the polymers indicated that for a semicrystalline polymer an epitaxial model can be employed to correlate and interrelate the ultrastructure morphology, surface chemistry, surface molecular motions, degrees and types of associated bound water and surface/subsurface ion binding to thrombogenesis. Further for an amorphous polymer, of given side chain length and chemistry, the results indicate that there is an initial effect of molecular motions on thrombogenesis, independent of morphological order/disorder and/or associated water.

Duke Scholars

Author William M. Reichert Biomedical Engineering