Keynote: DNA-based molecular devices


Journal Article

We overview recent work in the field of DNA-based autonomous biomolecular devices. We particularly emphasize molecular assemblies and molecular devices that are (i) self-assembled: that is they assemble into DNA nanostructures in one stage without explicit external control, (ii) programmable: the tasks the molecular devices execute can be modified without an entire redesign and (ii) autonomous: they operate without external mediation (e.g. thermal-cycling). We describe recent experimental progress in DNA-based autonomous biomolecular devices that achieve: 2D patterning, computation, amplified sensing, and molecular nano-scale transport. These have taken the technology from a state of intriguing possibilities into demonstrated capabilities of quickly increasing scale, and we describe a number of very promising applications in the biomedical industry. © 2011 IEEE.

Full Text

Duke Authors

Cited Authors

  • Reif, JH

Published Date

  • April 14, 2011

Published In

  • 2011 Ieee 1st International Conference on Computational Advances in Bio and Medical Sciences, Iccabs 2011

Start / End Page

  • 3 -

Digital Object Identifier (DOI)

  • 10.1109/ICCABS.2011.5729934

Citation Source

  • Scopus