Design of an autonomous DNA nanomechanical device capable of universal computation and universal translational motion


Journal Article

Intelligent nanomechanical devices that operate in an autonomous fashion are of great theoretical and practical interest. Recent successes in building large scale DNA nano-structures, in constructing DNA mechanical devices, and in DNA computing provide a solid foundation for the next step forward: designing autonomous DNA mechanical devices capable of arbitrarily complex behavior. One prototype system towards this goal can be an autonomous DNA mechanical device capable of universal computation, by mimicking the operation of a universal Turing machine. Building on our prior theoretical design and prototype experimental construction of an autonomous unidirectional DNA walking device moving along a linear track, we present here the design of a nanomechanical DNA device that autonomously mimics the operation of a 2-state 5-color universal Turing machine. Our autonomous nanomechanical device, called an Autonomous DNA Turing Machine (ADTM), is thus capable of universal computation and hence complex translational motion, which we define as universal transnational motion. © Springer-Verlag Berlin Heidelberg 2005.

Duke Authors

Cited Authors

  • Yin, P; Turberfield, AJ; Sahu, S; Reif, JH

Published Date

  • September 9, 2005

Published In

Volume / Issue

  • 3384 /

Start / End Page

  • 426 - 444

International Standard Serial Number (ISSN)

  • 0302-9743

Citation Source

  • Scopus