DNA-templated self-assembly of protein and nanoparticle linear arrays.

Journal Article (Journal Article)

Self-assembling DNA tiling lattices represent a versatile system for nanoscale construction. Self-assembled DNA arrays provide an excellent template for spatially positioning other molecules with increased relative precision and programmability. Here we report an experiment using a linear array of DNA triple crossover tiles to controllably template the self-assembly of single-layer or double-layer linear arrays of streptavidin molecules and streptavidin-conjugated nanogold particles through biotin-streptavidin interaction. The organization of streptavidin and its conjugated gold nanoparticles into periodic arrays was visualized by atomic force microscopy and scanning electron microscopy.

Full Text

Duke Authors

Cited Authors

  • Li, H; Park, SH; Reif, JH; LaBean, TH; Yan, H

Published Date

  • January 2004

Published In

Volume / Issue

  • 126 / 2

Start / End Page

  • 418 - 419

PubMed ID

  • 14719910

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja0383367


  • eng