Logical computation using algorithmic self-assembly of DNA triple-crossover molecules.
Published
Journal Article
Recent work has demonstrated the self-assembly of designed periodic two-dimensional arrays composed of DNA tiles, in which the intermolecular contacts are directed by 'sticky' ends. In a mathematical context, aperiodic mosaics may be formed by the self-assembly of 'Wang' tiles, a process that emulates the operation of a Turing machine. Macroscopic self-assembly has been used to perform computations; there is also a logical equivalence between DNA sticky ends and Wang tile edges. This suggests that the self-assembly of DNA-based tiles could be used to perform DNA-based computation. Algorithmic aperiodic self-assembly requires greater fidelity than periodic self-assembly, because correct tiles must compete with partially correct tiles. Here we report a one-dimensional algorithmic self-assembly of DNA triple-crossover molecules that can be used to execute four steps of a logical (cumulative XOR) operation on a string of binary bits.
Full Text
Duke Authors
Cited Authors
- Mao, C; LaBean, TH; Relf, JH; Seeman, NC
Published Date
- September 2000
Published In
Volume / Issue
- 407 / 6803
Start / End Page
- 493 - 496
PubMed ID
- 11028996
Pubmed Central ID
- 11028996
Electronic International Standard Serial Number (EISSN)
- 1476-4687
International Standard Serial Number (ISSN)
- 0028-0836
Digital Object Identifier (DOI)
- 10.1038/35035038
Language
- eng