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Independent segregation of alcohol intake and immobility in F2 progeny from FH/ ACI intercross

Publication ,  Journal Article
Parsian, A; Overstreet, DH; Rezvani, A
Published in: American Journal of Medical Genetics - Neuropsychiatric Genetics
August 7, 2000

The inbred Fawn-Hooded (FH/Wjd) strain of rats not only drinks substantial amounts of alcohol voluntarily compared to the inbred ACI (ACI/N) strain, they also exhibit exaggerated immobility in the forced swim test (measurement for depression), have high saccharin and total fluid intakes. Whether these differences are due to the pleiotropic effects of the same genes or due to the effects of independent genes can be evaluated, in part, by determining how these variables segregate in the F2 population. A total of 144 F2 (74 males and 70 females) rats from a cross between the FH/ Wjd strain and the ACI/N strain were tested with a behavioral battery. Analysis of variance determined that there were no litter effects on alcohol intake, nor did this measure vary with coat color. A correlation matrix was established for the 7 variables measured: water intake, forced alcohol intake, voluntary alcohol intake, alcohol preference, saccharin intake, total fluid intake, and immobility in the forced swim test. Voluntary alcohol intake was highly correlated (r = +0.914) with alcohol preference but was not significantly correlated with any other variables. Immobility was not significantly correlated with any of the other variables. Saccharin was significantly correlated with total fluid intake and forced alcohol intake. These findings of independent segregation of voluntary alcohol intake, saccharin intake and immobility in the F2 population of FH/ACI rats suggests that the differences in the parental strains may be the consequence of independent genetic factors. A QTL study of these animals could confirm this conclusion.

Duke Scholars

Published In

American Journal of Medical Genetics - Neuropsychiatric Genetics

EISSN

1552-485X

ISSN

1552-4841

Publication Date

August 7, 2000

Volume

96

Issue

4

Start / End Page

560

Related Subject Headings

  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 3105 Genetics
  • 1109 Neurosciences
  • 1103 Clinical Sciences
  • 0604 Genetics
 

Citation

APA
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ICMJE
MLA
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Parsian, A., Overstreet, D. H., & Rezvani, A. (2000). Independent segregation of alcohol intake and immobility in F2 progeny from FH/ ACI intercross. American Journal of Medical Genetics - Neuropsychiatric Genetics, 96(4), 560.
Parsian, A., D. H. Overstreet, and A. Rezvani. “Independent segregation of alcohol intake and immobility in F2 progeny from FH/ ACI intercross.” American Journal of Medical Genetics - Neuropsychiatric Genetics 96, no. 4 (August 7, 2000): 560.
Parsian A, Overstreet DH, Rezvani A. Independent segregation of alcohol intake and immobility in F2 progeny from FH/ ACI intercross. American Journal of Medical Genetics - Neuropsychiatric Genetics. 2000 Aug 7;96(4):560.
Parsian, A., et al. “Independent segregation of alcohol intake and immobility in F2 progeny from FH/ ACI intercross.” American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 96, no. 4, Aug. 2000, p. 560.
Parsian A, Overstreet DH, Rezvani A. Independent segregation of alcohol intake and immobility in F2 progeny from FH/ ACI intercross. American Journal of Medical Genetics - Neuropsychiatric Genetics. 2000 Aug 7;96(4):560.
Journal cover image

Published In

American Journal of Medical Genetics - Neuropsychiatric Genetics

EISSN

1552-485X

ISSN

1552-4841

Publication Date

August 7, 2000

Volume

96

Issue

4

Start / End Page

560

Related Subject Headings

  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 3105 Genetics
  • 1109 Neurosciences
  • 1103 Clinical Sciences
  • 0604 Genetics