Independent segregation of alcohol intake and immobility in F2 progeny from FH/ ACI intercross
The inbred Fawn-Hooded (FH/Wjd) strain of rats not only drinks substantial amounts of alcohol voluntarily compared to the inbred ACI (ACI/N) strain, they also exhibit exaggerated immobility in the forced swim test (measurement for depression), have high saccharin and total fluid intakes. Whether these differences are due to the pleiotropic effects of the same genes or due to the effects of independent genes can be evaluated, in part, by determining how these variables segregate in the F2 population. A total of 144 F2 (74 males and 70 females) rats from a cross between the FH/ Wjd strain and the ACI/N strain were tested with a behavioral battery. Analysis of variance determined that there were no litter effects on alcohol intake, nor did this measure vary with coat color. A correlation matrix was established for the 7 variables measured: water intake, forced alcohol intake, voluntary alcohol intake, alcohol preference, saccharin intake, total fluid intake, and immobility in the forced swim test. Voluntary alcohol intake was highly correlated (r = +0.914) with alcohol preference but was not significantly correlated with any other variables. Immobility was not significantly correlated with any of the other variables. Saccharin was significantly correlated with total fluid intake and forced alcohol intake. These findings of independent segregation of voluntary alcohol intake, saccharin intake and immobility in the F2 population of FH/ACI rats suggests that the differences in the parental strains may be the consequence of independent genetic factors. A QTL study of these animals could confirm this conclusion.
Parsian, A; Overstreet, DH; Rezvani, A
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