Combination pharmacotherapy in alcoholism: a novel treatment approach.

Journal Article (Journal Article)

Combination pharmacotherapy has proven effective in a number of psychiatric disorders, including depression and schizophrenia. However, compared with other affective disorders, few studies have explored the use of combination therapy in alcoholism, and the majority have been limited to animal models. There is evidence to support a role for combination therapy in alcoholism. For example, several neurochemical systems, including the dopaminergic, serotonergic, and opioidergic, appear to affect alcohol intake. Studies in several different types of alcohol-preferring rats have suggested that coadministration of agents to target more than one of these systems simultaneously may produce beneficial effects on alcohol intake, while avoiding problematic effects, such as alterations in food or water intake. Data from preliminary clinical studies have shown trends toward combination therapy reducing alcohol intake in humans. While such findings are encouraging, they must be explored further in larger, randomized, double-blind trials.

Full Text

Duke Authors

Cited Authors

  • Farren, CK; Rezvani, AH; Overstreet, D; O'Malley, S

Published Date

  • February 2000

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • 70 - 76

PubMed ID

  • 18297000

Pubmed Central ID

  • 18297000

International Standard Serial Number (ISSN)

  • 1092-8529

Digital Object Identifier (DOI)

  • 10.1017/s1092852900012839


  • eng

Conference Location

  • United States