Distribution of opioid peptide gene expression in the limbic system of Fawn-Hooded (alcohol-preferring) and Wistar-Kyoto (alcohol-non-preferring) rats.

Journal Article (Journal Article)

Preprodynorphin and preproenkephalin mRNA expression was examined in the CNS of two rat strains, the alcohol-preferring Fawn-Hooded (FH) and the alcohol-non-preferring Wistar-Kyoto (WKY), using in situ hybridisation histochemistry. Relative to the WKY, the FH showed significantly lower levels of preproenkephalin mRNA in the striatum and nucleus accumbens (-24% and -17% respectively), but a higher level of preprodynorphin mRNA in the hippocampus (+33%). The depressed level of preproenkephalin mRNA in the nucleus accumbens may be implicated in alcohol-seeking behaviour.

Full Text

Duke Authors

Cited Authors

  • Cowen, MS; Rezvani, A; Jarrott, B; Lawrence, AJ

Published Date

  • June 15, 1998

Published In

Volume / Issue

  • 796 / 1-2

Start / End Page

  • 323 - 326

PubMed ID

  • 9689488

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/s0006-8993(98)00432-6


  • eng

Conference Location

  • Netherlands