Distribution of opioid peptide gene expression in the limbic system of Fawn-Hooded (alcohol-preferring) and Wistar-Kyoto (alcohol-non-preferring) rats.
Journal Article (Journal Article)
Preprodynorphin and preproenkephalin mRNA expression was examined in the CNS of two rat strains, the alcohol-preferring Fawn-Hooded (FH) and the alcohol-non-preferring Wistar-Kyoto (WKY), using in situ hybridisation histochemistry. Relative to the WKY, the FH showed significantly lower levels of preproenkephalin mRNA in the striatum and nucleus accumbens (-24% and -17% respectively), but a higher level of preprodynorphin mRNA in the hippocampus (+33%). The depressed level of preproenkephalin mRNA in the nucleus accumbens may be implicated in alcohol-seeking behaviour.
Full Text
Duke Authors
Cited Authors
- Cowen, MS; Rezvani, A; Jarrott, B; Lawrence, AJ
Published Date
- June 15, 1998
Published In
Volume / Issue
- 796 / 1-2
Start / End Page
- 323 - 326
PubMed ID
- 9689488
International Standard Serial Number (ISSN)
- 0006-8993
Digital Object Identifier (DOI)
- 10.1016/s0006-8993(98)00432-6
Language
- eng
Conference Location
- Netherlands