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Distribution of opioid peptide gene expression in the limbic system of Fawn-Hooded (alcohol-preferring) and Wistar-Kyoto (alcohol-non-preferring) rats.

Publication ,  Journal Article
Cowen, MS; Rezvani, A; Jarrott, B; Lawrence, AJ
Published in: Brain Res
June 15, 1998

Preprodynorphin and preproenkephalin mRNA expression was examined in the CNS of two rat strains, the alcohol-preferring Fawn-Hooded (FH) and the alcohol-non-preferring Wistar-Kyoto (WKY), using in situ hybridisation histochemistry. Relative to the WKY, the FH showed significantly lower levels of preproenkephalin mRNA in the striatum and nucleus accumbens (-24% and -17% respectively), but a higher level of preprodynorphin mRNA in the hippocampus (+33%). The depressed level of preproenkephalin mRNA in the nucleus accumbens may be implicated in alcohol-seeking behaviour.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

June 15, 1998

Volume

796

Issue

1-2

Start / End Page

323 / 326

Location

Netherlands

Related Subject Headings

  • Tissue Distribution
  • Rats, Inbred WKY
  • Rats, Inbred Strains
  • Rats
  • RNA, Messenger
  • Protein Precursors
  • Neurology & Neurosurgery
  • Limbic System
  • In Situ Hybridization
  • Histocytochemistry
 

Citation

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MLA
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Cowen, M. S., Rezvani, A., Jarrott, B., & Lawrence, A. J. (1998). Distribution of opioid peptide gene expression in the limbic system of Fawn-Hooded (alcohol-preferring) and Wistar-Kyoto (alcohol-non-preferring) rats. Brain Res, 796(1–2), 323–326. https://doi.org/10.1016/s0006-8993(98)00432-6
Cowen, M. S., A. Rezvani, B. Jarrott, and A. J. Lawrence. “Distribution of opioid peptide gene expression in the limbic system of Fawn-Hooded (alcohol-preferring) and Wistar-Kyoto (alcohol-non-preferring) rats.Brain Res 796, no. 1–2 (June 15, 1998): 323–26. https://doi.org/10.1016/s0006-8993(98)00432-6.
Cowen, M. S., et al. “Distribution of opioid peptide gene expression in the limbic system of Fawn-Hooded (alcohol-preferring) and Wistar-Kyoto (alcohol-non-preferring) rats.Brain Res, vol. 796, no. 1–2, June 1998, pp. 323–26. Pubmed, doi:10.1016/s0006-8993(98)00432-6.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

June 15, 1998

Volume

796

Issue

1-2

Start / End Page

323 / 326

Location

Netherlands

Related Subject Headings

  • Tissue Distribution
  • Rats, Inbred WKY
  • Rats, Inbred Strains
  • Rats
  • RNA, Messenger
  • Protein Precursors
  • Neurology & Neurosurgery
  • Limbic System
  • In Situ Hybridization
  • Histocytochemistry