[3H]zolpidem binding in alcohol-preferring and non-preferring rat brain.

Journal Article (Journal Article)

The present study has employed in vitro autoradiography to study the distribution and density of [3H]zolpidem binding sites, which are regarded as an index of ethanol-sensitive gamma-aminobutyric acid (GABA)A receptors, in the brains of alcohol-preferring Fawn-Hooded (FH) rats compared to non-alcohol preferring Wistar-Kyoto (WKY) rats. Binding of [3H]zolpidem showed a similar distribution profile in both rat strains examined and included cerebellum, globus pallidus, nucleus of the solitary tract and a number of midbrain/hindbrain nuclei. Densitometric quantitation of binding revealed that FH rats possessed a significantly higher density of [3H]zolpidem binding compared to WKY rats in cortical regions, substantia nigra pars reticulata and the ventral pallidum. These data indicate that FH rats may have an increased number of ethanol-sensitive GABA(A) receptors in regions intimately involved in reward processes, and may partially explain the alcohol-seeking nature of the FH rat.

Full Text

Duke Authors

Cited Authors

  • Chen, F; Rezvani, A; Jarrott, B; Lawrence, AJ

Published Date

  • December 5, 1997

Published In

Volume / Issue

  • 238 / 3

Start / End Page

  • 103 - 106

PubMed ID

  • 9464630

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/s0304-3940(97)00867-7

Language

  • eng

Conference Location

  • Ireland