Behavioral differences between two inbred strains of Fawn-Hooded rat: a model of serotonin dysfunction.

Journal Article (Journal Article)

The Fawn-Hooded rat (FH) strain has attracted the attention of some psychopharmacologists because of reports of its exaggerated immobility in the swim test, hypercortisolemia, excessive voluntary intake of alcohol, platelet and central serotonin abnormalities and subsensitivity to serotonergic agonists. However, there appears to be some controversy over several behavioral and physiological characteristics of these rats. The present paper proposes that the lack of reproducible findings can be traced to there being several distinct inbred strains of FH rats. Of the two compared in this communication, the FH/Wjd strain is more immobile in the forced swim test, spends more time in the open arms of the elevated plus maze, and drinks more saccharin and alcohol voluntarily than the FH/Har (Iowa Reactive) strain. Future workers are cautioned to report the source of their FH rats.

Full Text

Duke Authors

Cited Authors

  • Overstreet, DH; Rezvani, AH

Published Date

  • December 1996

Published In

Volume / Issue

  • 128 / 3

Start / End Page

  • 328 - 330

PubMed ID

  • 8972553

International Standard Serial Number (ISSN)

  • 0033-3158

Digital Object Identifier (DOI)

  • 10.1007/s002130050141


  • eng

Conference Location

  • Germany