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Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats.

Publication ,  Journal Article
Rezvani, AH; Overstreet, DH; Lee, YW
Published in: Pharmacol Biochem Behav
November 1995

Alcohol-preferring (P), Fawn-Hooded (FH) and alcohol-accepting (AA) rats were injected intraperitoneally (IP) or subcutaneously (SC) with different doses (10, 30, and 60 mg/kg) of Ibogaine or vehicle. In a separate experiment, FH rats were administered intragastrically (IG) with either 60 mg/kg of Ibogaine or vehicle for 5 days. In addition, the effects of Ibogaine on blood alcohol concentrations were measured. Our data show that, contrary to the SC administration of Ibogaine, IP administration of the agent significantly and dose-dependently reduced alcohol intake in these rats. Subchronic IG administration of 60 mg/kg of Ibogaine into FH rats significantly reduced alcohol intake without the development of tolerance or a significant effect on food or water intake. A single IP injection of 60 mg/kg Ibogaine into FH rats did not affect the blood alcohol levels. These results show that Ibogaine when injected IP or IG, but not SC, can significantly reduce alcohol intake without an effect on blood alcohol concentrations or food intake. These findings may suggest the involvement of Ibogaine's metabolite(s) in reducing alcohol intake. Although the neuronal mechanism(s) of action of Ibogaine on the regulation of alcohol intake is not fully understood, it is speculated that Ibogaine or its metabolite(s) exerts its attenuating effect on alcohol intake by modulating neurotransmitters/neuromodulators proposed to be involved in regulation of alcohol consumption.

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Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

November 1995

Volume

52

Issue

3

Start / End Page

615 / 620

Location

United States

Related Subject Headings

  • Rats
  • Neurology & Neurosurgery
  • Male
  • Ibogaine
  • Ethanol
  • Eating
  • Drinking Behavior
  • Dose-Response Relationship, Drug
  • Animals
  • Alcohol Drinking
 

Citation

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Rezvani, A. H., Overstreet, D. H., & Lee, Y. W. (1995). Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats. Pharmacol Biochem Behav, 52(3), 615–620. https://doi.org/10.1016/0091-3057(95)00152-m
Rezvani, A. H., D. H. Overstreet, and Y. W. Lee. “Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats.Pharmacol Biochem Behav 52, no. 3 (November 1995): 615–20. https://doi.org/10.1016/0091-3057(95)00152-m.
Rezvani AH, Overstreet DH, Lee YW. Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats. Pharmacol Biochem Behav. 1995 Nov;52(3):615–20.
Rezvani, A. H., et al. “Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats.Pharmacol Biochem Behav, vol. 52, no. 3, Nov. 1995, pp. 615–20. Pubmed, doi:10.1016/0091-3057(95)00152-m.
Rezvani AH, Overstreet DH, Lee YW. Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats. Pharmacol Biochem Behav. 1995 Nov;52(3):615–620.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

November 1995

Volume

52

Issue

3

Start / End Page

615 / 620

Location

United States

Related Subject Headings

  • Rats
  • Neurology & Neurosurgery
  • Male
  • Ibogaine
  • Ethanol
  • Eating
  • Drinking Behavior
  • Dose-Response Relationship, Drug
  • Animals
  • Alcohol Drinking