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Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains.

Publication ,  Journal Article
Overstreet, DH; Kampov-Polevoy, AB; Rezvani, AH; Murrelle, L; Halikas, JA; Janowsky, DS
Published in: Alcohol Clin Exp Res
April 1993

Saccharin and ethanol intakes were measured in seven strains of rats known to differ in their preferences for ethanol: The Fawn-Hooded (FH), alcohol-preferring (P) and Maudsley Reactive rats have been reported to drink ethanol voluntarily, whereas the alcohol-nonpreferring, Maudsley Nonreactive and Flinders Line (FSL and FRL) rats do not. Saccharin and ethanol intakes were highly correlated (r = +0.61) over all strains, with the FH rats drinking the most of both solutions. Correlation coefficients between pairs of drinking versus nondrinking rat strains were even higher. In a second experiment, genetically heterogeneous F2 progeny from cross-breeding the ethanol-preferring FH rats with the ethanol-nonpreferring Flinders Resistant Line (FRL) rats were studied. The results indicated a high positive correlation between saccharin and ethanol intakes (+0.65). These findings suggest that the association between saccharin and ethanol intakes previously reported in rat strains with different preferences for ethanol may have a similar genetic basis.

Duke Scholars

Published In

Alcohol Clin Exp Res

DOI

ISSN

0145-6008

Publication Date

April 1993

Volume

17

Issue

2

Start / End Page

366 / 369

Location

England

Related Subject Headings

  • Taste
  • Substance Abuse
  • Species Specificity
  • Saccharin
  • Rats, Inbred Strains
  • Rats
  • Male
  • Genotype
  • Drinking
  • Arousal
 

Citation

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ICMJE
MLA
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Overstreet, D. H., Kampov-Polevoy, A. B., Rezvani, A. H., Murrelle, L., Halikas, J. A., & Janowsky, D. S. (1993). Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcohol Clin Exp Res, 17(2), 366–369. https://doi.org/10.1111/j.1530-0277.1993.tb00777.x
Overstreet, D. H., A. B. Kampov-Polevoy, A. H. Rezvani, L. Murrelle, J. A. Halikas, and D. S. Janowsky. “Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains.Alcohol Clin Exp Res 17, no. 2 (April 1993): 366–69. https://doi.org/10.1111/j.1530-0277.1993.tb00777.x.
Overstreet DH, Kampov-Polevoy AB, Rezvani AH, Murrelle L, Halikas JA, Janowsky DS. Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcohol Clin Exp Res. 1993 Apr;17(2):366–9.
Overstreet, D. H., et al. “Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains.Alcohol Clin Exp Res, vol. 17, no. 2, Apr. 1993, pp. 366–69. Pubmed, doi:10.1111/j.1530-0277.1993.tb00777.x.
Overstreet DH, Kampov-Polevoy AB, Rezvani AH, Murrelle L, Halikas JA, Janowsky DS. Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcohol Clin Exp Res. 1993 Apr;17(2):366–369.
Journal cover image

Published In

Alcohol Clin Exp Res

DOI

ISSN

0145-6008

Publication Date

April 1993

Volume

17

Issue

2

Start / End Page

366 / 369

Location

England

Related Subject Headings

  • Taste
  • Substance Abuse
  • Species Specificity
  • Saccharin
  • Rats, Inbred Strains
  • Rats
  • Male
  • Genotype
  • Drinking
  • Arousal