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Verapamil suppresses d-amphetamine-induced place preference conditioning.

Publication ,  Journal Article
Pucilowski, O; Garges, PL; Rezvani, AH; Hutheson, S; Janowsky, DS
Published in: Eur J Pharmacol
August 10, 1993

The effect of pretreatment with (+/-)-verapamil (5, 10 or 15 mg/kg, i.p.) on place preference induced with d-amphetamine (1 mg/kg, i.p. 40 min after verapamil) was studied in male rats. Place preference conditioning was performed using two-compartment shuttle boxes and 8 alternating stimulant/saline sessions. Verapamil dose-dependently suppressed amphetamine-induced place preference. No significant changes in place preference were observed following 8 alternating verapamil (no stimulant)/saline sessions, irrespective of whether verapamil injections were paired with the originally less or the originally more preferred compartment. It appears that verapamil effectively suppresses the reinforcing properties of d-amphetamine in the paradigm used.

Duke Scholars

Published In

Eur J Pharmacol

DOI

ISSN

0014-2999

Publication Date

August 10, 1993

Volume

240

Issue

1

Start / End Page

89 / 92

Location

Netherlands

Related Subject Headings

  • Verapamil
  • Reinforcement, Psychology
  • Rats, Wistar
  • Rats
  • Pharmacology & Pharmacy
  • Male
  • Dextroamphetamine
  • Conditioning, Psychological
  • Behavioral Science & Comparative Psychology
  • Animals
 

Citation

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Pucilowski, O., Garges, P. L., Rezvani, A. H., Hutheson, S., & Janowsky, D. S. (1993). Verapamil suppresses d-amphetamine-induced place preference conditioning. Eur J Pharmacol, 240(1), 89–92. https://doi.org/10.1016/0014-2999(93)90551-r
Pucilowski, O., P. L. Garges, A. H. Rezvani, S. Hutheson, and D. S. Janowsky. “Verapamil suppresses d-amphetamine-induced place preference conditioning.Eur J Pharmacol 240, no. 1 (August 10, 1993): 89–92. https://doi.org/10.1016/0014-2999(93)90551-r.
Pucilowski O, Garges PL, Rezvani AH, Hutheson S, Janowsky DS. Verapamil suppresses d-amphetamine-induced place preference conditioning. Eur J Pharmacol. 1993 Aug 10;240(1):89–92.
Pucilowski, O., et al. “Verapamil suppresses d-amphetamine-induced place preference conditioning.Eur J Pharmacol, vol. 240, no. 1, Aug. 1993, pp. 89–92. Pubmed, doi:10.1016/0014-2999(93)90551-r.
Pucilowski O, Garges PL, Rezvani AH, Hutheson S, Janowsky DS. Verapamil suppresses d-amphetamine-induced place preference conditioning. Eur J Pharmacol. 1993 Aug 10;240(1):89–92.
Journal cover image

Published In

Eur J Pharmacol

DOI

ISSN

0014-2999

Publication Date

August 10, 1993

Volume

240

Issue

1

Start / End Page

89 / 92

Location

Netherlands

Related Subject Headings

  • Verapamil
  • Reinforcement, Psychology
  • Rats, Wistar
  • Rats
  • Pharmacology & Pharmacy
  • Male
  • Dextroamphetamine
  • Conditioning, Psychological
  • Behavioral Science & Comparative Psychology
  • Animals