Verapamil suppresses d-amphetamine-induced place preference conditioning.

Published

Journal Article

The effect of pretreatment with (+/-)-verapamil (5, 10 or 15 mg/kg, i.p.) on place preference induced with d-amphetamine (1 mg/kg, i.p. 40 min after verapamil) was studied in male rats. Place preference conditioning was performed using two-compartment shuttle boxes and 8 alternating stimulant/saline sessions. Verapamil dose-dependently suppressed amphetamine-induced place preference. No significant changes in place preference were observed following 8 alternating verapamil (no stimulant)/saline sessions, irrespective of whether verapamil injections were paired with the originally less or the originally more preferred compartment. It appears that verapamil effectively suppresses the reinforcing properties of d-amphetamine in the paradigm used.

Full Text

Duke Authors

Cited Authors

  • Pucilowski, O; Garges, PL; Rezvani, AH; Hutheson, S; Janowsky, DS

Published Date

  • August 10, 1993

Published In

Volume / Issue

  • 240 / 1

Start / End Page

  • 89 - 92

PubMed ID

  • 8405127

Pubmed Central ID

  • 8405127

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/0014-2999(93)90551-r

Language

  • eng

Conference Location

  • Netherlands