Effect of calcium-channel blockers on alcohol consumption in alcohol-drinking monkeys.

Published

Journal Article

Experiments were performed to determine the effect of the calcium-channel blockers verapamil and diltiazem on ethanol preference in monkeys. Two days of administration of 10 mg/kg verapamil but not diltiazem or saline significantly decreased ethanol intake in all monkeys tested. Chronic treatment with verapamil, but not saline, dose-dependently attenuated alcohol intake, without significantly influencing water intake. These findings suggest that verapamil exerts an inhibitory action on ethanol preference in chronically alcohol-drinking monkeys, possibly by interfering with Ca(2+)-channels and/or by interacting with the activity of certain central neurotransmitters.

Full Text

Duke Authors

Cited Authors

  • Rezvani, AH; Grady, DR; Janowsky, DS

Published Date

  • January 1, 1991

Published In

Volume / Issue

  • 26 / 2

Start / End Page

  • 161 - 167

PubMed ID

  • 1652252

Pubmed Central ID

  • 1652252

Electronic International Standard Serial Number (EISSN)

  • 1464-3502

International Standard Serial Number (ISSN)

  • 0735-0414

Digital Object Identifier (DOI)

  • 10.1093/oxfordjournals.alcalc.a045097

Language

  • eng