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Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats.

Publication ,  Journal Article
Pucilowski, O; Overstreet, DH; Rezvani, AH; Janowsky, DS
Published in: J Pharm Pharmacol
June 1991

The Flinders Sensitive Line of rats (FSL) has been selectively bred to have increased sensitivity to cholinergic drugs. Typically, these rats react with twice as great a hypothermic effect to muscarinic agonists such as oxotremorine, as do similarly bred Flinders Resistant Line rats (FRL). We compared the effects of three chemically different calcium channel inhibitors (diltiazem, nicardipine and verapamil) on the hypothermia induced in FRL and FSL rats by oxotremorine (0.2 mg kg-1 s.c.). Each drug was injected i.p. in a dose of 20 mumol kg-1 30 min before oxotremorine. Methylatropine (2 mg kg-1 s.c.) was administered 15 min before oxotremorine to block the peripheral effects of the agonist. The hypothermic effect of oxotremorine in FSL rats was antagonized by nicardipine and diltiazem. In contrast, verapamil failed to influence the hypothermic response in FSL rats. Verapamil significantly (P less than 0.05) augmented oxotremorine hypothermia in FRL rats. Diltiazem and nicardipine were without effect on oxotremorine-induced hypothermia in FRL rats. There were no significant changes in temperature in separate groups of FRL and FSL rats treated with calcium channel inhibitors alone.

Duke Scholars

Published In

J Pharm Pharmacol

DOI

ISSN

0022-3573

Publication Date

June 1991

Volume

43

Issue

6

Start / End Page

436 / 439

Location

England

Related Subject Headings

  • Receptors, N-Methyl-D-Aspartate
  • Rats, Inbred Strains
  • Rats
  • Quinpirole
  • Piperazines
  • Pharmacology & Pharmacy
  • Parasympathetic Nervous System
  • Oxotremorine
  • Male
  • Ergolines
 

Citation

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Pucilowski, O., Overstreet, D. H., Rezvani, A. H., & Janowsky, D. S. (1991). Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats. J Pharm Pharmacol, 43(6), 436–439. https://doi.org/10.1111/j.2042-7158.1991.tb03505.x
Pucilowski, O., D. H. Overstreet, A. H. Rezvani, and D. S. Janowsky. “Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats.J Pharm Pharmacol 43, no. 6 (June 1991): 436–39. https://doi.org/10.1111/j.2042-7158.1991.tb03505.x.
Pucilowski O, Overstreet DH, Rezvani AH, Janowsky DS. Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats. J Pharm Pharmacol. 1991 Jun;43(6):436–9.
Pucilowski, O., et al. “Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats.J Pharm Pharmacol, vol. 43, no. 6, June 1991, pp. 436–39. Pubmed, doi:10.1111/j.2042-7158.1991.tb03505.x.
Pucilowski O, Overstreet DH, Rezvani AH, Janowsky DS. Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats. J Pharm Pharmacol. 1991 Jun;43(6):436–439.

Published In

J Pharm Pharmacol

DOI

ISSN

0022-3573

Publication Date

June 1991

Volume

43

Issue

6

Start / End Page

436 / 439

Location

England

Related Subject Headings

  • Receptors, N-Methyl-D-Aspartate
  • Rats, Inbred Strains
  • Rats
  • Quinpirole
  • Piperazines
  • Pharmacology & Pharmacy
  • Parasympathetic Nervous System
  • Oxotremorine
  • Male
  • Ergolines