MK-801 potently inhibits alcohol withdrawal seizures in rats.
Published
Journal Article
The ability of MK-801, an N-methyl-D-aspartate (NMDA)-channel antagonist, to suppress alcohol withdrawal seizures generated audio-genically was studied in adult male rats using a cross-over experimental design. MK-801 treatment reduced overall seizure score and proportion of rats seizing. In comparison to other seizure models, alcohol withdrawal seizures seem to be particularly sensitive to MK-801, suggesting that mechanisms which result in seizure susceptibility after withdrawal of chronic ethanol exposure may be dependent upon sensitization or upregulation of NMDA processes.
Full Text
Duke Authors
Cited Authors
- Morrisett, RA; Rezvani, AH; Overstreet, D; Janowsky, DS; Wilson, WA; Swartzwelder, HS
Published Date
- January 25, 1990
Published In
Volume / Issue
- 176 / 1
Start / End Page
- 103 - 105
PubMed ID
- 2155795
Pubmed Central ID
- 2155795
International Standard Serial Number (ISSN)
- 0014-2999
Digital Object Identifier (DOI)
- 10.1016/0014-2999(90)90138-v
Language
- eng
Conference Location
- Netherlands