MK-801 potently inhibits alcohol withdrawal seizures in rats.

Journal Article (Journal Article)

The ability of MK-801, an N-methyl-D-aspartate (NMDA)-channel antagonist, to suppress alcohol withdrawal seizures generated audio-genically was studied in adult male rats using a cross-over experimental design. MK-801 treatment reduced overall seizure score and proportion of rats seizing. In comparison to other seizure models, alcohol withdrawal seizures seem to be particularly sensitive to MK-801, suggesting that mechanisms which result in seizure susceptibility after withdrawal of chronic ethanol exposure may be dependent upon sensitization or upregulation of NMDA processes.

Full Text

Duke Authors

Cited Authors

  • Morrisett, RA; Rezvani, AH; Overstreet, D; Janowsky, DS; Wilson, WA; Swartzwelder, HS

Published Date

  • January 25, 1990

Published In

Volume / Issue

  • 176 / 1

Start / End Page

  • 103 - 105

PubMed ID

  • 2155795

Pubmed Central ID

  • 2155795

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/0014-2999(90)90138-v

Language

  • eng

Conference Location

  • Netherlands