Anticentromere antibody. Clinical Correlations and association with favorable prognosis in patients with scleroderma variants.

Journal Article (Journal Article)

The presence of antibody to the chromosomal centromere appears to be associated with a subset of patients with the limited CREST form of scleroderma. To further define the prognostic value of this autoantibody, 27 patients, who were identified as having anticentromere antibody by screening antinuclear antibody tests using HEp-2 cell substrates, were followed clinically and serologically for 2 years. The presence of anticentromere antibody is common in the limited CREST forms of systemic sclerosis, and it is often the only autoantibody specificity present in the sera of patients with the CREST variant. When compared with other patients who exhibit speckled or nucleolar antinuclear antibody patterns, those with anticentromere antibody had significantly less major organ system involvement.

Full Text

Duke Authors

Cited Authors

  • McCarty, GA; Rice, JR; Bembe, ML; Barada, FA

Published Date

  • January 1983

Published In

Volume / Issue

  • 26 / 1

Start / End Page

  • 1 - 7

PubMed ID

  • 6337593

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/art.1780260101


  • eng

Conference Location

  • United States