Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues.

Journal Article (Journal Article)

Synthesis and biological evaluation of two naturally-occurring bromotyramines, moloka'iamine 1 and 3,5-dibromo-4-methoxy-beta-phenethylamine 2, together with several analogues, have been completed. Bromotyramine 2 is cytotoxic, and was found to be a potent antifoulant. Analogues 15 and 16 also displayed significant cytotoxic and antifouling activities.

Full Text

Duke Authors

Cited Authors

  • Schoenfeld, RC; Conova, S; Rittschof, D; Ganem, B

Published Date

  • March 2002

Published In

Volume / Issue

  • 12 / 5

Start / End Page

  • 823 - 825

PubMed ID

  • 11859011

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(02)00022-7


  • eng