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Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues.

Publication ,  Journal Article
Schoenfeld, RC; Conova, S; Rittschof, D; Ganem, B
Published in: Bioorganic & medicinal chemistry letters
March 2002

Synthesis and biological evaluation of two naturally-occurring bromotyramines, moloka'iamine 1 and 3,5-dibromo-4-methoxy-beta-phenethylamine 2, together with several analogues, have been completed. Bromotyramine 2 is cytotoxic, and was found to be a potent antifoulant. Analogues 15 and 16 also displayed significant cytotoxic and antifouling activities.

Duke Scholars

Published In

Bioorganic & medicinal chemistry letters

DOI

EISSN

1464-3405

ISSN

0960-894X

Publication Date

March 2002

Volume

12

Issue

5

Start / End Page

823 / 825

Related Subject Headings

  • Tyramine
  • Tumor Cells, Cultured
  • Molecular Structure
  • Medicinal & Biomolecular Chemistry
  • Marine Biology
  • Humans
  • Drug Screening Assays, Antitumor
  • Cell Survival
  • Bacteria
  • Antibiotics, Antineoplastic
 

Citation

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Schoenfeld, R. C., Conova, S., Rittschof, D., & Ganem, B. (2002). Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues. Bioorganic & Medicinal Chemistry Letters, 12(5), 823–825. https://doi.org/10.1016/s0960-894x(02)00022-7
Schoenfeld, Ryan C., Susan Conova, Daniel Rittschof, and Bruce Ganem. “Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues.Bioorganic & Medicinal Chemistry Letters 12, no. 5 (March 2002): 823–25. https://doi.org/10.1016/s0960-894x(02)00022-7.
Schoenfeld RC, Conova S, Rittschof D, Ganem B. Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues. Bioorganic & medicinal chemistry letters. 2002 Mar;12(5):823–5.
Schoenfeld, Ryan C., et al. “Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues.Bioorganic & Medicinal Chemistry Letters, vol. 12, no. 5, Mar. 2002, pp. 823–25. Epmc, doi:10.1016/s0960-894x(02)00022-7.
Schoenfeld RC, Conova S, Rittschof D, Ganem B. Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues. Bioorganic & medicinal chemistry letters. 2002 Mar;12(5):823–825.
Journal cover image

Published In

Bioorganic & medicinal chemistry letters

DOI

EISSN

1464-3405

ISSN

0960-894X

Publication Date

March 2002

Volume

12

Issue

5

Start / End Page

823 / 825

Related Subject Headings

  • Tyramine
  • Tumor Cells, Cultured
  • Molecular Structure
  • Medicinal & Biomolecular Chemistry
  • Marine Biology
  • Humans
  • Drug Screening Assays, Antitumor
  • Cell Survival
  • Bacteria
  • Antibiotics, Antineoplastic