The gelatinous bone marrow (serous atrophy) in patients with acquired immunodeficiency syndrome. Evidence of excess sulfated glycosaminoglycan.

Published

Journal Article

Patients with the acquired immunodeficiency syndrome uniformly exhibit hematologic abnormalities characterized by anemia and/or pancytopenia. In a study of 75 consecutive bone marrow biopsy specimens from patients with acquired immunodeficiency syndrome, 29% exhibited serous atrophy, characterized by marrow hypoplasia, fat atrophy, and deposition of extracellular "gelatinous" material (gelatinous transformation). The latter material was composed exclusively of glycosaminoglycans (alcian blue positive at pHs of 2.5 and 1.0, and sensitive to testicular hyaluronidase digestion). Excess glycosaminoglycan, which significantly alters the bone marrow microenvironment, is detrimental to erythropoiesis. The present findings support the concept that the damaged hematopoietic inductive microenvironment in patients with acquired immunodeficiency syndrome leads to failure of hematopoiesis, and, hence, to peripheral hematologic abnormalities.

Full Text

Duke Authors

Cited Authors

  • Mehta, K; Gascon, P; Robboy, S

Published Date

  • May 1992

Published In

Volume / Issue

  • 116 / 5

Start / End Page

  • 504 - 508

PubMed ID

  • 1580754

Pubmed Central ID

  • 1580754

International Standard Serial Number (ISSN)

  • 0003-9985

Language

  • eng

Conference Location

  • United States