Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.

Published

Journal Article

The present study demonstrates that immune tolerance can be achieved in the thymus both by clonal deletion and by clonal inactivation, but that the two tolerant states are induced by cellular elements with different radiation sensitivities. TCR engagement of self antigens on bone marrow-derived, radiation-sensitive (presumably dendritic) cells induces clonal deletion of developing thymocytes, whereas TCR engagement of self antigens on radiation-resistant cellular elements, such as thymic epithelium, induces clonal anergy. The nondeleted, anergic thymocytes can express IL-2-Rs but are unable to proliferate in response to either specific antigen or anti-TCR antibodies, and do develop into phenotypically mature cells that emigrate out of the thymus and into the periphery.

Full Text

Duke Authors

Cited Authors

  • Roberts, JL; Sharrow, SO; Singer, A

Published Date

  • March 1, 1990

Published In

Volume / Issue

  • 171 / 3

Start / End Page

  • 935 - 940

PubMed ID

  • 2307937

Pubmed Central ID

  • 2307937

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.171.3.935

Language

  • eng

Conference Location

  • United States