Mismatch repair proteins and mitotic genome stability.

Journal Article (Journal Article;Review)

Mismatch repair (MMR) proteins play a critical role in maintaining the mitotic stability of eukaryotic genomes. MMR proteins repair errors made during DNA replication and in their absence, mutations accumulate at elevated rates. In addition, MMR proteins inhibit recombination between non-identical DNA sequences, and hence prevent genome rearrangements resulting from interactions between repetitive elements. This review provides an overview of the anti-mutator and anti-recombination functions of MMR proteins in the yeast Saccharomyces cerevisiae.

Full Text

Duke Authors

Cited Authors

  • Harfe, BD; Jinks-Robertson, S

Published Date

  • June 30, 2000

Published In

Volume / Issue

  • 451 / 1-2

Start / End Page

  • 151 - 167

PubMed ID

  • 10915870

International Standard Serial Number (ISSN)

  • 0027-5107

Digital Object Identifier (DOI)

  • 10.1016/s0027-5107(00)00047-6


  • eng

Conference Location

  • Netherlands