DNA mismatch repair and genetic instability.

Published

Journal Article (Review)

Mismatch repair (MMR) systems play a central role in promoting genetic stability by repairing DNA replication errors, inhibiting recombination between non-identical DNA sequences and participating in responses to DNA damage. The discovery of a link between human cancer and MMR defects has led to an explosion of research on eukaryotic MMR. The key proteins in MMR are highly conserved from bacteria to mammals, and this conservation has been critical for defining the components of eukaryotic MMR systems. In eukaryotes, there are multiple homologs of the key bacterial MutS and MutL MMR proteins, and these homologs form heterodimers that have discrete roles in MMR-related processes. This review describes the genetic and biochemical approaches used to study MMR, and summarizes the diverse roles that MMR proteins play in maintaining genetic stability.

Full Text

Duke Authors

Cited Authors

  • Harfe, BD; Jinks-Robertson, S

Published Date

  • 2000

Published In

Volume / Issue

  • 34 /

Start / End Page

  • 359 - 399

PubMed ID

  • 11092832

Pubmed Central ID

  • 11092832

International Standard Serial Number (ISSN)

  • 0066-4197

Digital Object Identifier (DOI)

  • 10.1146/annurev.genet.34.1.359

Language

  • eng

Conference Location

  • United States