Association of increased spontaneous mutation rates with high levels of transcription in yeast.
Publication
, Journal Article
Datta, A; Jinks-Robertson, S
Published in: Science
June 16, 1995
Complex processes such as transcription, replication, repair, and recombination require changes in chromatin structure and the interactions of numerous trans-acting factors with DNA sequences, raising the possibility that these processes may be interrelated. Here the effect of transcription on the rate of spontaneous mutation in the yeast Saccharomyces cerevisiae was examined. With the use of a lys2 frameshift allele under the control of a highly inducible promoter, the rate of spontaneous reversion was shown to increase when the mutant gene was highly transcribed. Thus, transcriptionally active DNA and enhanced spontaneous mutation rates are associated in yeast.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
June 16, 1995
Volume
268
Issue
5217
Start / End Page
1616 / 1619
Location
United States
Related Subject Headings
- Transformation, Genetic
- Transcription, Genetic
- Saccharomyces cerevisiae
- Promoter Regions, Genetic
- Phenotype
- Mutation
- Lysine
- Genes, Fungal
- General Science & Technology
- Frameshift Mutation
Citation
APA
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ICMJE
MLA
NLM
Datta, A., & Jinks-Robertson, S. (1995). Association of increased spontaneous mutation rates with high levels of transcription in yeast. Science, 268(5217), 1616–1619. https://doi.org/10.1126/science.7777859
Datta, A., and S. Jinks-Robertson. “Association of increased spontaneous mutation rates with high levels of transcription in yeast.” Science 268, no. 5217 (June 16, 1995): 1616–19. https://doi.org/10.1126/science.7777859.
Datta A, Jinks-Robertson S. Association of increased spontaneous mutation rates with high levels of transcription in yeast. Science. 1995 Jun 16;268(5217):1616–9.
Datta, A., and S. Jinks-Robertson. “Association of increased spontaneous mutation rates with high levels of transcription in yeast.” Science, vol. 268, no. 5217, June 1995, pp. 1616–19. Pubmed, doi:10.1126/science.7777859.
Datta A, Jinks-Robertson S. Association of increased spontaneous mutation rates with high levels of transcription in yeast. Science. 1995 Jun 16;268(5217):1616–1619.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
June 16, 1995
Volume
268
Issue
5217
Start / End Page
1616 / 1619
Location
United States
Related Subject Headings
- Transformation, Genetic
- Transcription, Genetic
- Saccharomyces cerevisiae
- Promoter Regions, Genetic
- Phenotype
- Mutation
- Lysine
- Genes, Fungal
- General Science & Technology
- Frameshift Mutation