Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure.
Publication
, Journal Article
Perrino, C; Rockman, HA
Published in: Curr Opin Cardiol
September 2007
PURPOSE OF REVIEW: Heart failure is a common clinical syndrome, and despite intensive medical therapy it remains a leading cause of global morbidity and mortality. Pathological stimuli promote a general remodeling process in the heart. RECENT FINDINGS: Recent animal studies have highlighted very promising novel therapeutic possibilities, based on the regulation of adrenergic receptor function, and novel signaling pathways are being discovered that could be relevant for future molecular approaches. SUMMARY: This review highlights some of the novel approaches to reverse pathological remodeling and improve cardiac dysfunction, placing emphasis on strategies targeting the adrenergic receptors.
Duke Scholars
Published In
Curr Opin Cardiol
DOI
ISSN
0268-4705
Publication Date
September 2007
Volume
22
Issue
5
Start / End Page
443 / 449
Location
United States
Related Subject Headings
- Ventricular Remodeling
- Receptors, Adrenergic
- Phosphatidylinositol 3-Kinases
- Mice
- Humans
- Heart Failure
- GTP-Binding Protein Regulators
- G-Protein-Coupled Receptor Kinase 2
- Cardiovascular System & Hematology
- Cardiomegaly
Citation
APA
Chicago
ICMJE
MLA
NLM
Perrino, C., & Rockman, H. A. (2007). Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure. Curr Opin Cardiol, 22(5), 443–449. https://doi.org/10.1097/HCO.0b013e3282294d72
Perrino, Cinzia, and Howard A. Rockman. “Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure.” Curr Opin Cardiol 22, no. 5 (September 2007): 443–49. https://doi.org/10.1097/HCO.0b013e3282294d72.
Perrino C, Rockman HA. Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure. Curr Opin Cardiol. 2007 Sep;22(5):443–9.
Perrino, Cinzia, and Howard A. Rockman. “Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure.” Curr Opin Cardiol, vol. 22, no. 5, Sept. 2007, pp. 443–49. Pubmed, doi:10.1097/HCO.0b013e3282294d72.
Perrino C, Rockman HA. Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure. Curr Opin Cardiol. 2007 Sep;22(5):443–449.
Published In
Curr Opin Cardiol
DOI
ISSN
0268-4705
Publication Date
September 2007
Volume
22
Issue
5
Start / End Page
443 / 449
Location
United States
Related Subject Headings
- Ventricular Remodeling
- Receptors, Adrenergic
- Phosphatidylinositol 3-Kinases
- Mice
- Humans
- Heart Failure
- GTP-Binding Protein Regulators
- G-Protein-Coupled Receptor Kinase 2
- Cardiovascular System & Hematology
- Cardiomegaly