Cardiac GPCRs: GPCR signaling in healthy and failing hearts.

Published

Journal Article (Review)

G protein-coupled receptors (GPCRs) are widely implicated in human heart disease, making them an important target for cardiac drug therapy. The most commonly studied and clinically targeted cardiac GPCRs include the adrenergic, angiotensin, endothelin, and adenosine receptors. Treatment options focusing on the complex and integrated signaling pathways of these GPCRs are critical for the understanding and amelioration of heart disease. The focus of this review is to highlight the most commonly studied and clinically targeted cardiac GPCRs, placing emphasis on their common signaling components implicated in cardiac disease.

Full Text

Duke Authors

Cited Authors

  • Salazar, NC; Chen, J; Rockman, HA

Published Date

  • April 2007

Published In

Volume / Issue

  • 1768 / 4

Start / End Page

  • 1006 - 1018

PubMed ID

  • 17376402

Pubmed Central ID

  • 17376402

Electronic International Standard Serial Number (EISSN)

  • 1878-2434

International Standard Serial Number (ISSN)

  • 0006-3002

Digital Object Identifier (DOI)

  • 10.1016/j.bbamem.2007.02.010

Language

  • eng