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Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment.

Publication ,  Journal Article
Tilley, DG; Rockman, HA
Published in: Expert Rev Cardiovasc Ther
May 2006

The use of beta-blockers to antagonize beta-adrenergic receptor signaling in the heart has become a standard method of treatment for heart failure, resulting in positive clinical outcomes alone and in conjunction with other modulators of cardiomyocyte contractility. However, an entire explanation for improved cardiac function in patients using beta-blockers is unknown, and in fact may be quite complicated, considering the numerous intracellular signaling pathways associated with beta-adrenergic receptors. Stimulation of beta-adrenergic receptors during both normal conditions and during heart failure activate several distinct signaling cascades, which influence cardiomyocyte contraction, hypertrophy and apoptosis. This review explores the signaling cascades induced by beta-adrenergic receptor activation in normal and desensitized states to provide new insight into the effective treatment of cardiac dysfunction.

Duke Scholars

Published In

Expert Rev Cardiovasc Ther

DOI

EISSN

1744-8344

Publication Date

May 2006

Volume

4

Issue

3

Start / End Page

417 / 432

Location

England

Related Subject Headings

  • beta-Arrestins
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Polymorphism, Genetic
  • Humans
  • Heart Failure
  • G-Protein-Coupled Receptor Kinase 1
  • Cardiovascular System & Hematology
  • Cardiomegaly
  • Calcium-Calmodulin-Dependent Protein Kinases
 

Citation

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Tilley, D. G., & Rockman, H. A. (2006). Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment. Expert Rev Cardiovasc Ther, 4(3), 417–432. https://doi.org/10.1586/14779072.4.3.417
Tilley, Douglas G., and Howard A. Rockman. “Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment.Expert Rev Cardiovasc Ther 4, no. 3 (May 2006): 417–32. https://doi.org/10.1586/14779072.4.3.417.
Tilley, Douglas G., and Howard A. Rockman. “Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment.Expert Rev Cardiovasc Ther, vol. 4, no. 3, May 2006, pp. 417–32. Pubmed, doi:10.1586/14779072.4.3.417.
Journal cover image

Published In

Expert Rev Cardiovasc Ther

DOI

EISSN

1744-8344

Publication Date

May 2006

Volume

4

Issue

3

Start / End Page

417 / 432

Location

England

Related Subject Headings

  • beta-Arrestins
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Polymorphism, Genetic
  • Humans
  • Heart Failure
  • G-Protein-Coupled Receptor Kinase 1
  • Cardiovascular System & Hematology
  • Cardiomegaly
  • Calcium-Calmodulin-Dependent Protein Kinases