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Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction.

Publication ,  Journal Article
Perrino, C; Esposito, G; Rockman, HA
Published in: Panminerva Med
September 2005

Heart failure is a common clinical syndrome characterized by increased levels of circulating catecholamines and extensive abnormalities in the beta-adrenergic receptor (betaAR) system. Interestingly, whether dampening of betaAR signals is beneficial or detrimental for the failing cardiomyocyte is still controversial. In this review we will discuss a number of studies addressing the role of betaAR dysfunction in the development and progression of cardiomyocyte failure, and novel possible strategies to ameliorate cardiomyocyte contractility in heart failure through the normalization of betaAR signaling.

Duke Scholars

Published In

Panminerva Med

ISSN

0031-0808

Publication Date

September 2005

Volume

47

Issue

3

Start / End Page

143 / 155

Location

Italy

Related Subject Headings

  • beta-Adrenergic Receptor Kinases
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Phosphoinositide-3 Kinase Inhibitors
  • Myocytes, Cardiac
  • Myocardial Contraction
  • Humans
  • Heart Failure
  • G-Protein-Coupled Receptor Kinase 2
  • Cardiovascular System & Hematology
 

Citation

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Perrino, C., Esposito, G., & Rockman, H. A. (2005). Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction. Panminerva Med, 47(3), 143–155.
Perrino, C., G. Esposito, and H. A. Rockman. “Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction.Panminerva Med 47, no. 3 (September 2005): 143–55.
Perrino C, Esposito G, Rockman HA. Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction. Panminerva Med. 2005 Sep;47(3):143–55.
Perrino, C., et al. “Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction.Panminerva Med, vol. 47, no. 3, Sept. 2005, pp. 143–55.
Perrino C, Esposito G, Rockman HA. Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction. Panminerva Med. 2005 Sep;47(3):143–155.

Published In

Panminerva Med

ISSN

0031-0808

Publication Date

September 2005

Volume

47

Issue

3

Start / End Page

143 / 155

Location

Italy

Related Subject Headings

  • beta-Adrenergic Receptor Kinases
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Phosphoinositide-3 Kinase Inhibitors
  • Myocytes, Cardiac
  • Myocardial Contraction
  • Humans
  • Heart Failure
  • G-Protein-Coupled Receptor Kinase 2
  • Cardiovascular System & Hematology