Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction.

Journal Article (Review)

Heart failure is a common clinical syndrome characterized by increased levels of circulating catecholamines and extensive abnormalities in the beta-adrenergic receptor (betaAR) system. Interestingly, whether dampening of betaAR signals is beneficial or detrimental for the failing cardiomyocyte is still controversial. In this review we will discuss a number of studies addressing the role of betaAR dysfunction in the development and progression of cardiomyocyte failure, and novel possible strategies to ameliorate cardiomyocyte contractility in heart failure through the normalization of betaAR signaling.

Full Text

Duke Authors

Cited Authors

  • Perrino, C; Esposito, G; Rockman, HA

Published Date

  • September 2005

Published In

Volume / Issue

  • 47 / 3

Start / End Page

  • 143 - 155

PubMed ID

  • 16462723

International Standard Serial Number (ISSN)

  • 0031-0808

Language

  • eng

Conference Location

  • Italy