Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction.
Publication
, Journal Article
Perrino, C; Esposito, G; Rockman, HA
Published in: Panminerva Med
September 2005
Heart failure is a common clinical syndrome characterized by increased levels of circulating catecholamines and extensive abnormalities in the beta-adrenergic receptor (betaAR) system. Interestingly, whether dampening of betaAR signals is beneficial or detrimental for the failing cardiomyocyte is still controversial. In this review we will discuss a number of studies addressing the role of betaAR dysfunction in the development and progression of cardiomyocyte failure, and novel possible strategies to ameliorate cardiomyocyte contractility in heart failure through the normalization of betaAR signaling.
Duke Scholars
Published In
Panminerva Med
ISSN
0031-0808
Publication Date
September 2005
Volume
47
Issue
3
Start / End Page
143 / 155
Location
Italy
Related Subject Headings
- beta-Adrenergic Receptor Kinases
- Signal Transduction
- Receptors, Adrenergic, beta
- Phosphoinositide-3 Kinase Inhibitors
- Myocytes, Cardiac
- Myocardial Contraction
- Humans
- Heart Failure
- G-Protein-Coupled Receptor Kinase 2
- Cardiovascular System & Hematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Perrino, C., Esposito, G., & Rockman, H. A. (2005). Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction. Panminerva Med, 47(3), 143–155.
Perrino, C., G. Esposito, and H. A. Rockman. “Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction.” Panminerva Med 47, no. 3 (September 2005): 143–55.
Perrino C, Esposito G, Rockman HA. Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction. Panminerva Med. 2005 Sep;47(3):143–55.
Perrino, C., et al. “Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction.” Panminerva Med, vol. 47, no. 3, Sept. 2005, pp. 143–55.
Perrino C, Esposito G, Rockman HA. Defects in cardiomyocyte function: role of beta-adrenergic receptor dysfunction. Panminerva Med. 2005 Sep;47(3):143–155.
Published In
Panminerva Med
ISSN
0031-0808
Publication Date
September 2005
Volume
47
Issue
3
Start / End Page
143 / 155
Location
Italy
Related Subject Headings
- beta-Adrenergic Receptor Kinases
- Signal Transduction
- Receptors, Adrenergic, beta
- Phosphoinositide-3 Kinase Inhibitors
- Myocytes, Cardiac
- Myocardial Contraction
- Humans
- Heart Failure
- G-Protein-Coupled Receptor Kinase 2
- Cardiovascular System & Hematology