The role of G-protein-coupled receptors in heart failure


Journal Article (Review)

Central to the development of congestive heart failure is the role by G-protein-coupled receptors (GPCRs). The sympathetic nervous system stimulates GPCRs during periods of stress. Novel therapeutic approaches to heart failure are focused on key enzymes that regulate the transduction pathways. The purpose of this review is to document the mechanism by which an alteration in the GPCR transduction processes contributes to the pathophysiology of heart failure. © 2004 Elsevier Ltd. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Lemaire, A; Rockman, HA

Published Date

  • January 1, 2004

Published In

Volume / Issue

  • 1 / 1

Start / End Page

  • 37 - 43

International Standard Serial Number (ISSN)

  • 1740-6765

Digital Object Identifier (DOI)

  • 10.1016/j.ddmec.2004.08.013

Citation Source

  • Scopus