HIV-1 dynamics in children.


Journal Article

HIV-1-infected children have higher plasma viral loads and progress to disease more quickly than infected adults. To gain insight into the accelerated pathogenesis of HIV-1 in children, viral dynamics were measured following the initiation of highly active antiretroviral therapy (HAART) and compared with those reported for adults. A biphasic decline in plasma HIV-1 RNA was observed, with a rapid decrease during the first 1 to 2 weeks of therapy (phase I) followed by a slower decline (phase II). The phase I and II decay rates were not significantly different among children of different ages, pretherapy plasma HIV-1 RNA levels, or CD4 cell counts. Estimated phase I decay rates were similar to those previously reported in adults with a mean of 0.43 days(-1) and a half-life of 1.6 days. The phase II decay rates were slower in children compared with adults with a mean of 0.016 days(-1) versus 0.066 days(-1), and a half-life of 43.3 versus 14.1 days, respectively (p < .05). The mean time required to reach viral levels below detection thresholds was also longer in these children compared with that in adults. These data suggest that HIV-1 dynamics may be different in children, and that these differences may necessitate different treatment strategies.

Full Text

Cited Authors

  • Melvin, AJ; Rodrigo, AG; Mohan, KM; Lewis, PA; Manns-Arcuino, L; Coombs, RW; Mullins, JI; Frenkel, LM

Published Date

  • April 1999

Published In

Volume / Issue

  • 20 / 5

Start / End Page

  • 468 - 473

PubMed ID

  • 10225229

Pubmed Central ID

  • 10225229

International Standard Serial Number (ISSN)

  • 1077-9450

Digital Object Identifier (DOI)

  • 10.1097/00042560-199904150-00009


  • eng