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Neurocognitive function in destination therapy patients receiving continuous-flow vs pulsatile-flow left ventricular assist device support.

Publication ,  Journal Article
Petrucci, RJ; Rogers, JG; Blue, L; Gallagher, C; Russell, SD; Dordunoo, D; Jaski, BE; Chillcott, S; Sun, B; Yanssens, TL; Tatooles, A ...
Published in: J Heart Lung Transplant
January 2012

BACKGROUND: The HeartMate II (Thoratec Corp, Pleasanton, CA) continuous-flow left ventricular assist device (LVAD) improved survival in destination therapy (DT) patients during a randomized trial compared with pulsatile-flow LVADs. This study documented changes in cognitive performance in DT patients from that trial to determine if there were differences between continuous-flow and pulsatile-flow support. METHODS: Data were collected in a sub-study from 96 HeartMate II continuous-flow and 30 HeartMate XVE pulsatile-flow LVAD patients from 12 of the 35 trial sites that followed the same serial neurocognitive (NC) testing protocol at 1, 3, 6, 12, and 24 months after LVAD implantation. Spatial perception, memory, language, executive functions, and processing speed were the domains assessed with 10 standard cognitive measures. Differences over time and between LVAD type were evaluated with linear mixed-effects modeling. RESULTS: From 1 to 24 months after LVAD implantation, changes in NC functions were stable or showed improvement in all domains, and there were no differences between the continuous-flow and pulsatile-flow groups. Data at 24 months were only available from patients with the continuous-flow LVAD due to the limited durability of the HeartMate XVE device. There was no decline in any NC domain over the time of LVAD support. Missing data not collected from patients who died could have resulted in a bias toward inflated study results. CONCLUSIONS: The NC performance of advanced heart failure patients supported with continuous-flow and pulsatile-flow LVADs shows stabilization or improvement during support for up to 24 months.

Duke Scholars

Published In

J Heart Lung Transplant

DOI

EISSN

1557-3117

Publication Date

January 2012

Volume

31

Issue

1

Start / End Page

27 / 36

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Surgery
  • Prosthesis Design
  • Middle Aged
  • Memory
  • Male
  • Humans
  • Heart-Assist Devices
  • Heart Transplantation
  • Heart Failure
 

Citation

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Petrucci, R. J., Rogers, J. G., Blue, L., Gallagher, C., Russell, S. D., Dordunoo, D., … Slaughter, M. S. (2012). Neurocognitive function in destination therapy patients receiving continuous-flow vs pulsatile-flow left ventricular assist device support. J Heart Lung Transplant, 31(1), 27–36. https://doi.org/10.1016/j.healun.2011.10.012
Petrucci, Ralph J., Joseph G. Rogers, Laura Blue, Colleen Gallagher, Stuart D. Russell, Dzifa Dordunoo, Brian E. Jaski, et al. “Neurocognitive function in destination therapy patients receiving continuous-flow vs pulsatile-flow left ventricular assist device support.J Heart Lung Transplant 31, no. 1 (January 2012): 27–36. https://doi.org/10.1016/j.healun.2011.10.012.
Petrucci RJ, Rogers JG, Blue L, Gallagher C, Russell SD, Dordunoo D, et al. Neurocognitive function in destination therapy patients receiving continuous-flow vs pulsatile-flow left ventricular assist device support. J Heart Lung Transplant. 2012 Jan;31(1):27–36.
Petrucci, Ralph J., et al. “Neurocognitive function in destination therapy patients receiving continuous-flow vs pulsatile-flow left ventricular assist device support.J Heart Lung Transplant, vol. 31, no. 1, Jan. 2012, pp. 27–36. Pubmed, doi:10.1016/j.healun.2011.10.012.
Petrucci RJ, Rogers JG, Blue L, Gallagher C, Russell SD, Dordunoo D, Jaski BE, Chillcott S, Sun B, Yanssens TL, Tatooles A, Koundakjian L, Farrar DJ, Slaughter MS. Neurocognitive function in destination therapy patients receiving continuous-flow vs pulsatile-flow left ventricular assist device support. J Heart Lung Transplant. 2012 Jan;31(1):27–36.
Journal cover image

Published In

J Heart Lung Transplant

DOI

EISSN

1557-3117

Publication Date

January 2012

Volume

31

Issue

1

Start / End Page

27 / 36

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Surgery
  • Prosthesis Design
  • Middle Aged
  • Memory
  • Male
  • Humans
  • Heart-Assist Devices
  • Heart Transplantation
  • Heart Failure