Skip to main content

Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers.

Publication ,  Journal Article
Lockey, JE; Roggli, VL; Hilbert, TJ; Rice, CH; Levin, LS; Borton, EK; Biddinger, PW; Lemasters, GK
Published in: J Occup Environ Med
July 2012

OBJECTIVE: The biopersistence of refractory ceramic fiber (RCF) in human lung tissue is unknown and may contribute to an association between cumulative fiber exposure and radiographic changes. METHODS: Lung tissue fiber was analyzed for a case series of 10 RCF workers and a 20-year longitudinal chest radiograph study of 1323 workers was conducted. RESULTS: Within lung tissue, RCF comprised 14% to 100% of fibers 5 μm or more in length and was identified up to 20 years after RCF employment. Among workers with no reported asbestos exposure, cumulative exposure of more than 63 to 110 and more than 110 fiber-months/cm was associated with radiographic pleural changes of 8.5% (odds ratio, 7.2; 95% confidence interval, 1.4 to 36.8) and 11.6% (odds ratio, 10.3; 95% confidence interval, 2.1 to 49.9), respectively. CONCLUSIONS: Refractory ceramic fiber can persist in human lung tissue for up to 20 years and may contribute to the significant association between cumulative fiber exposure and radiographic pleural changes.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Occup Environ Med

DOI

EISSN

1536-5948

Publication Date

July 2012

Volume

54

Issue

7

Start / End Page

781 / 788

Location

United States

Related Subject Headings

  • Radiography
  • Pleura
  • Occupational Exposure
  • Mineral Fibers
  • Middle Aged
  • Male
  • Lung
  • Longitudinal Studies
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lockey, J. E., Roggli, V. L., Hilbert, T. J., Rice, C. H., Levin, L. S., Borton, E. K., … Lemasters, G. K. (2012). Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers. J Occup Environ Med, 54(7), 781–788. https://doi.org/10.1097/JOM.0b013e31825296fd
Lockey, James E., Victor L. Roggli, Timothy J. Hilbert, Carol H. Rice, Linda S. Levin, Eric K. Borton, Paul W. Biddinger, and Grace K. Lemasters. “Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers.J Occup Environ Med 54, no. 7 (July 2012): 781–88. https://doi.org/10.1097/JOM.0b013e31825296fd.
Lockey JE, Roggli VL, Hilbert TJ, Rice CH, Levin LS, Borton EK, et al. Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers. J Occup Environ Med. 2012 Jul;54(7):781–8.
Lockey, James E., et al. “Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers.J Occup Environ Med, vol. 54, no. 7, July 2012, pp. 781–88. Pubmed, doi:10.1097/JOM.0b013e31825296fd.
Lockey JE, Roggli VL, Hilbert TJ, Rice CH, Levin LS, Borton EK, Biddinger PW, Lemasters GK. Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers. J Occup Environ Med. 2012 Jul;54(7):781–788.

Published In

J Occup Environ Med

DOI

EISSN

1536-5948

Publication Date

July 2012

Volume

54

Issue

7

Start / End Page

781 / 788

Location

United States

Related Subject Headings

  • Radiography
  • Pleura
  • Occupational Exposure
  • Mineral Fibers
  • Middle Aged
  • Male
  • Lung
  • Longitudinal Studies
  • Humans
  • Female