Skip to main content

Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma.

Publication ,  Journal Article
Travis, WD; Garg, K; Franklin, WA; Wistuba, II; Sabloff, B; Noguchi, M; Kakinuma, R; Zakowski, M; Ginsberg, M; Padera, R; Jacobson, F; Kerr, K ...
Published in: J Clin Oncol
May 10, 2005

PURPOSE: To review recent advances in pathology and computed tomography (CT) of lung adenocarcinoma and bronchioloalveolar carcinoma (BAC). METHODS: A pathology/CT review panel of pathologists and radiologists met during a November 2004 International Association for the Study of Lung Cancer/American Society of Clinical Oncology consensus workshop in New York. The purpose was to determine if existing data was sufficient to propose modification of criteria for adenocarcinoma and BAC as newly published in the 2004 WHO Classification of Lung Tumors, and to address the pathologic/radiologic concept of diffuse/multicentric BAC. RESULTS: Solitary small, peripheral BACs have an excellent prognosis. Most lung adenocarcinomas with a BAC pattern are not pure BAC, but rather adenocarcinoma, mixed subtype with invasive patterns. This applies to tumors presenting with a diffuse/multinodular as well as solitary nodule pattern. The percent of BAC versus invasive components in lung adenocarcinomas appears to be prognostically important. However, a consensus definition of "minimally invasive" BAC with a favorable prognosis could not be achieved. While recognition of a BAC component is possible, the diagnosis of BAC with exclusion of invasive adenocarcinoma cannot be made by small biopsy or cytology specimens. CONCLUSION: There is a need to work toward a mutual understanding and consensus between pathologists, clinicians, and researchers with the use of the term BAC versus adenocarcinoma. Future studies should make some attempt to quantitate these components and/or other features such as size of scar, size of invasive component, or pattern of invasion. Hopefully, this work will allow definition of a category of adenocarcinoma, mixed subtype with predominant BAC/minimal invasion and a favorable prognosis.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

May 10, 2005

Volume

23

Issue

14

Start / End Page

3279 / 3287

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Lung Neoplasms
  • Humans
  • Adenocarcinoma, Bronchiolo-Alveolar
  • Adenocarcinoma
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Travis, W. D., Garg, K., Franklin, W. A., Wistuba, I. I., Sabloff, B., Noguchi, M., … Vazquez, M. (2005). Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma. J Clin Oncol, 23(14), 3279–3287. https://doi.org/10.1200/JCO.2005.15.776
Travis, William D., Kavita Garg, Wilbur A. Franklin, Ignacio I. Wistuba, Bradley Sabloff, Masayuki Noguchi, Ryutaro Kakinuma, et al. “Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma.J Clin Oncol 23, no. 14 (May 10, 2005): 3279–87. https://doi.org/10.1200/JCO.2005.15.776.
Travis WD, Garg K, Franklin WA, Wistuba II, Sabloff B, Noguchi M, et al. Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma. J Clin Oncol. 2005 May 10;23(14):3279–87.
Travis, William D., et al. “Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma.J Clin Oncol, vol. 23, no. 14, May 2005, pp. 3279–87. Pubmed, doi:10.1200/JCO.2005.15.776.
Travis WD, Garg K, Franklin WA, Wistuba II, Sabloff B, Noguchi M, Kakinuma R, Zakowski M, Ginsberg M, Padera R, Jacobson F, Johnson BE, Hirsch F, Brambilla E, Flieder DB, Geisinger KR, Thunnisen F, Kerr K, Yankelevitz D, Franks TJ, Galvin JR, Henderson DW, Nicholson AG, Hasleton PS, Roggli V, Tsao M-S, Cappuzzo F, Vazquez M. Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma. J Clin Oncol. 2005 May 10;23(14):3279–3287.

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

May 10, 2005

Volume

23

Issue

14

Start / End Page

3279 / 3287

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Lung Neoplasms
  • Humans
  • Adenocarcinoma, Bronchiolo-Alveolar
  • Adenocarcinoma
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences