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Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.

Publication ,  Journal Article
Uhl, GR; Drgon, T; Johnson, C; Ramoni, MF; Behm, FM; Rose, JE
Published in: Mol Med
2010

Abilities to successfully quit smoking display substantial evidence for heritability in classic and molecular genetic studies. Genome-wide association (GWA) studies have demonstrated single-nucleotide polymorphisms (SNPs) and haplotypes that distinguish successful quitters from individuals who were unable to quit smoking in clinical trial participants and in community samples. Many of the subjects in these clinical trial samples were aided by nicotine replacement therapy (NRT). We now report novel GWA results from participants in a clinical trial that sought dose/response relationships for "precessation" NRT. In this trial, 369 European-American smokers were randomized to 21 or 42 mg NRT, initiated 2 wks before target quit dates. Ten-week continuous smoking abstinence was assessed on the basis of self-reports and carbon monoxide levels. SNP genotyping used Affymetrix 6.0 arrays. GWA results for smoking cessation success provided no P value that reached "genome-wide" significance. Compared with chance, these results do identify (a) more clustering of nominally positive results within small genomic regions, (b) more overlap between these genomic regions and those identified in six prior successful smoking cessation GWA studies and (c) sets of genes that fall into gene ontology categories that appear to be biologically relevant. The 1,000 SNPs with the strongest associations form a plausible Bayesian network; no such network is formed by randomly selected sets of SNPs. The data provide independent support, based on individual genotyping, for many loci previously nominated on the basis of data from genotyping in pooled DNA samples. These results provide further support for the idea that aid for smoking cessation may be personalized on the basis of genetic predictors of outcome.

Duke Scholars

Published In

Mol Med

DOI

EISSN

1528-3658

Publication Date

2010

Volume

16

Issue

11-12

Start / End Page

513 / 526

Location

England

Related Subject Headings

  • Treatment Outcome
  • Tobacco Use Disorder
  • Smoking Cessation
  • Smoking
  • Polymorphism, Single Nucleotide
  • Nicotine
  • Immunology
  • Humans
  • Genotype
  • Genome-Wide Association Study
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Uhl, G. R., Drgon, T., Johnson, C., Ramoni, M. F., Behm, F. M., & Rose, J. E. (2010). Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement. Mol Med, 16(11–12), 513–526. https://doi.org/10.2119/molmed.2010.00052
Uhl, George R., Tomas Drgon, Catherine Johnson, Marco F. Ramoni, Frederique M. Behm, and Jed E. Rose. “Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.Mol Med 16, no. 11–12 (2010): 513–26. https://doi.org/10.2119/molmed.2010.00052.
Uhl GR, Drgon T, Johnson C, Ramoni MF, Behm FM, Rose JE. Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement. Mol Med. 2010;16(11–12):513–26.
Uhl, George R., et al. “Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.Mol Med, vol. 16, no. 11–12, 2010, pp. 513–26. Pubmed, doi:10.2119/molmed.2010.00052.
Uhl GR, Drgon T, Johnson C, Ramoni MF, Behm FM, Rose JE. Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement. Mol Med. 2010;16(11–12):513–526.

Published In

Mol Med

DOI

EISSN

1528-3658

Publication Date

2010

Volume

16

Issue

11-12

Start / End Page

513 / 526

Location

England

Related Subject Headings

  • Treatment Outcome
  • Tobacco Use Disorder
  • Smoking Cessation
  • Smoking
  • Polymorphism, Single Nucleotide
  • Nicotine
  • Immunology
  • Humans
  • Genotype
  • Genome-Wide Association Study