Objective: To assess the combination of the nicotine inhaler and nicotine patch for smoking cessation. Methods: Thirty healthy volunteers were enrolled into this open-label clinical trial of the combined use of nicotine inhalers and patches (15mg/16hr) for 6 weeks, and then nicotine inhalers alone for an additional 6 weeks. Results: Compared to baseline, the percentage salivary cotinine replacement at the end of Week 1 was 74%. One week point abstinence at 6 weeks was 43.3% (95% CL=26%, 61%), and at 12 weeks was 30.0% (95% CL=14%, 46%). Conclusion: The combination of the nicotine inhaler and nicotine patch appears safe and tolerable when used for smoking cessation.