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Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression.

Publication ,  Journal Article
Chauhan, SK; El Annan, J; Ecoiffier, T; Goyal, S; Zhang, Q; Saban, DR; Dana, R
Published in: J Immunol
February 1, 2009

Dry eye disease (DED), an inflammatory autoimmune disorder affecting the ocular surface, degrades visual performance and the quality of life of >10 million people in the United States alone. The primary limitation in the effective treatment of DED is an incomplete understanding of its specific cellular and molecular pathogenic elements. Using a validated mouse model of DED, herein we functionally characterize the different T cell subsets, including regulatory T cells (Tregs) and pathogenic effector T cells, and determine their contribution to the pathogenesis of DED. Our data demonstrate the presence of dysfunctional Tregs and the resistance of pathogenic T cells, particularly Th17 cells, to Treg suppression in DED. In addition, we clearly show that in vivo blockade of IL-17 significantly reduces the severity and progression of disease, which is paralleled by a reduction in the expansion of Th17 cells and restoration of Treg function. Our findings elucidate involvement of a previously unknown pathogenic T cell subset (Th17) in DED that is associated specifically with Treg dysfunction and disease pathogenesis and suggest a new target for dry eye therapy.

Duke Scholars

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Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

February 1, 2009

Volume

182

Issue

3

Start / End Page

1247 / 1252

Location

United States

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes, Helper-Inducer
  • Severity of Illness Index
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Activation
  • Lymph Nodes
  • Interleukin-17
  • Immunology
  • Immunity, Innate
 

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Chauhan, S. K., El Annan, J., Ecoiffier, T., Goyal, S., Zhang, Q., Saban, D. R., & Dana, R. (2009). Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. J Immunol, 182(3), 1247–1252. https://doi.org/10.4049/jimmunol.182.3.1247
Chauhan, Sunil K., Jaafar El Annan, Tatiana Ecoiffier, Sunali Goyal, Qiang Zhang, Daniel R. Saban, and Reza Dana. “Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression.J Immunol 182, no. 3 (February 1, 2009): 1247–52. https://doi.org/10.4049/jimmunol.182.3.1247.
Chauhan SK, El Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban DR, et al. Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. J Immunol. 2009 Feb 1;182(3):1247–52.
Chauhan, Sunil K., et al. “Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression.J Immunol, vol. 182, no. 3, Feb. 2009, pp. 1247–52. Pubmed, doi:10.4049/jimmunol.182.3.1247.
Chauhan SK, El Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban DR, Dana R. Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. J Immunol. 2009 Feb 1;182(3):1247–1252.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

February 1, 2009

Volume

182

Issue

3

Start / End Page

1247 / 1252

Location

United States

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes, Helper-Inducer
  • Severity of Illness Index
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Activation
  • Lymph Nodes
  • Interleukin-17
  • Immunology
  • Immunity, Innate