Personalized treatment of lung cancer.
Lung cancer is a heterogenous group of disorders, and a difficult disease to treat. The traditional approach of surgical resection for early-stage disease, potentially followed by chemotherapy, as well chemotherapy (with or without radiation) in later stages of disease is being supplemented with a personalized approach. The personalized approach has classically been used by the oncologist based on clinical/pathological parameters such as the performance status of the patient and histology of lung cancer. As molecular mechanisms have been explored in lung cancer more recently, the personalized approach also has incorporated molecular abnormalities. In particular, EGFR, K-ras, ALK, MET, CBL, and COX2, have come to the forefront as potential biomarkers and therapeutic targets. Thus, we review the various molecular mechanisms in lung cancer and the role of novel therapeutics.
Duke Scholars
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Related Subject Headings
- Receptors, Growth Factor
- Proto-Oncogene Proteins c-met
- Prognosis
- Precision Medicine
- Oncology & Carcinogenesis
- Oncogene Proteins, Fusion
- Neoplastic Cells, Circulating
- Mutation
- Lung Neoplasms
- Humans
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Receptors, Growth Factor
- Proto-Oncogene Proteins c-met
- Prognosis
- Precision Medicine
- Oncology & Carcinogenesis
- Oncogene Proteins, Fusion
- Neoplastic Cells, Circulating
- Mutation
- Lung Neoplasms
- Humans