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MET and phosphorylated MET as potential biomarkers in lung cancer.

Publication ,  Journal Article
Tretiakova, M; Salama, AKS; Karrison, T; Ferguson, MK; Husain, AN; Vokes, EE; Salgia, R
Published in: J Environ Pathol Toxicol Oncol
2011

This study aimed to investigate the expression and prognostic role of the receptor tyrosine kinase MET, phosphorylated MET, and the ligand hepatocyte growth factor (HGF) in patients with lung cancer. This retrospective study included 129 patients with non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with available tumor tissue and survival data. MET, pMET, and HGF expression were assessed using immunohistochemistry. MET, pMET, and HGF were more highly expressed in tumor tissue when compared to the adjacent lung parenchyma. A specific localization pattern was also evident: membranous, cytoplasmic, and nuclear patterns of expression were seen for MET, pMET, and HGF. In addition, high expression of two specific forms of phosphorylated MET--cytoplasmic expression of Y1003 and nuclear expression of Y1365--appeared to correlate with a worse overall survival (P = .016; hazard ratio [HR], 1.86; 95% confidence interval [95% CI], 1.12- 3.07; and P = .034; HR, 1.70; 95% CI, 1.04-2.78, respectively). In summary, MET, pMET, and HGF are highly expressed in both NSCLC and SCLC. Specific forms of pMET may serve as potential biomarkers in lung cancer.

Duke Scholars

Published In

J Environ Pathol Toxicol Oncol

DOI

EISSN

2162-6537

Publication Date

2011

Volume

30

Issue

4

Start / End Page

341 / 354

Location

United States

Related Subject Headings

  • Small Cell Lung Carcinoma
  • Retrospective Studies
  • Proto-Oncogene Proteins c-met
  • Phosphorylation
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Hepatocyte Growth Factor
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tretiakova, M., Salama, A. K. S., Karrison, T., Ferguson, M. K., Husain, A. N., Vokes, E. E., & Salgia, R. (2011). MET and phosphorylated MET as potential biomarkers in lung cancer. J Environ Pathol Toxicol Oncol, 30(4), 341–354. https://doi.org/10.1615/jenvironpatholtoxicoloncol.v30.i4.70
Tretiakova, Maria, April K. S. Salama, Theodore Karrison, Mark K. Ferguson, Aliya N. Husain, Everett E. Vokes, and Ravi Salgia. “MET and phosphorylated MET as potential biomarkers in lung cancer.J Environ Pathol Toxicol Oncol 30, no. 4 (2011): 341–54. https://doi.org/10.1615/jenvironpatholtoxicoloncol.v30.i4.70.
Tretiakova M, Salama AKS, Karrison T, Ferguson MK, Husain AN, Vokes EE, et al. MET and phosphorylated MET as potential biomarkers in lung cancer. J Environ Pathol Toxicol Oncol. 2011;30(4):341–54.
Tretiakova, Maria, et al. “MET and phosphorylated MET as potential biomarkers in lung cancer.J Environ Pathol Toxicol Oncol, vol. 30, no. 4, 2011, pp. 341–54. Pubmed, doi:10.1615/jenvironpatholtoxicoloncol.v30.i4.70.
Tretiakova M, Salama AKS, Karrison T, Ferguson MK, Husain AN, Vokes EE, Salgia R. MET and phosphorylated MET as potential biomarkers in lung cancer. J Environ Pathol Toxicol Oncol. 2011;30(4):341–354.
Journal cover image

Published In

J Environ Pathol Toxicol Oncol

DOI

EISSN

2162-6537

Publication Date

2011

Volume

30

Issue

4

Start / End Page

341 / 354

Location

United States

Related Subject Headings

  • Small Cell Lung Carcinoma
  • Retrospective Studies
  • Proto-Oncogene Proteins c-met
  • Phosphorylation
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Hepatocyte Growth Factor