Reirradiation for recurrent head and neck cancer.

Journal Article (Journal Article;Review)

Recurrence of head and neck cancer in a previously irradiated volume presents a challenging problem and has poor prognosis. A minority of patients are eligible for the preferred therapy, surgical resection. Systemic therapy is offered to patients with unresectable disease but offers little, if any, chance of cure. Repeat irradiation with systemic therapy is a potentially curative option. One randomized trial and several cooperative group and institutional studies support its use. Long-term disease-free survival has been observed, albeit with the risk of significant, possibly life threatening, late complications. Intensity-modulated radiotherapy has been shown to reduce toxicity and improve disease control. Novel systemic therapies and radiotherapy techniques, including stereotactic body radiotherapy, are under active study.

Full Text

Duke Authors

Cited Authors

  • Patel, PR; Salama, JK

Published Date

  • September 2012

Published In

Volume / Issue

  • 12 / 9

Start / End Page

  • 1177 - 1189

PubMed ID

  • 23098118

Electronic International Standard Serial Number (EISSN)

  • 1744-8328

Digital Object Identifier (DOI)

  • 10.1586/era.12.97


  • eng

Conference Location

  • England