Regulatory T cells move in when gliomas say "I Do".
Journal Article (Journal Article)
Indoleamine 2,3-dioxygenase (IDO) is an enzyme with known immunosuppressive and tolerogenic effects in cancer. Mounting evidence has associated IDO expression with the induction of regulatory T cells (Treg) and malignant progression. IDO inhibition may therefore provide a promising therapeutic approach for glioblastoma, where the need for novel treatment is great.
Full Text
Duke Authors
Cited Authors
- Choi, BD; Fecci, PE; Sampson, JH
Published Date
- November 15, 2012
Published In
Volume / Issue
- 18 / 22
Start / End Page
- 6086 - 6088
PubMed ID
- 23052252
Pubmed Central ID
- PMC3662964
Electronic International Standard Serial Number (EISSN)
- 1557-3265
Digital Object Identifier (DOI)
- 10.1158/1078-0432.CCR-12-2801
Language
- eng
Conference Location
- United States