Regulatory T cells move in when gliomas say "I Do".

Published

Journal Article

Indoleamine 2,3-dioxygenase (IDO) is an enzyme with known immunosuppressive and tolerogenic effects in cancer. Mounting evidence has associated IDO expression with the induction of regulatory T cells (Treg) and malignant progression. IDO inhibition may therefore provide a promising therapeutic approach for glioblastoma, where the need for novel treatment is great.

Full Text

Duke Authors

Cited Authors

Choi, BD; Fecci, PE; Sampson, JH

Published Date

November 15, 2012

Published In

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

Volume / Issue

18 / 22

Start / End Page

6086 - 6088

PubMed ID

23052252

Pubmed Central ID

23052252

International Standard Serial Number (ISSN)

1078-0432

Digital Object Identifier (DOI)

10.1158/1078-0432.CCR-12-2801

Language

eng

Conference Location

United States