Regulatory T cells move in when gliomas say "I Do".

Journal Article (Journal Article)

Indoleamine 2,3-dioxygenase (IDO) is an enzyme with known immunosuppressive and tolerogenic effects in cancer. Mounting evidence has associated IDO expression with the induction of regulatory T cells (Treg) and malignant progression. IDO inhibition may therefore provide a promising therapeutic approach for glioblastoma, where the need for novel treatment is great.

Full Text

Duke Authors

Cited Authors

  • Choi, BD; Fecci, PE; Sampson, JH

Published Date

  • November 15, 2012

Published In

Volume / Issue

  • 18 / 22

Start / End Page

  • 6086 - 6088

PubMed ID

  • 23052252

Pubmed Central ID

  • PMC3662964

Electronic International Standard Serial Number (EISSN)

  • 1557-3265

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-12-2801

Language

  • eng

Conference Location

  • United States