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Immunotherapy approaches for malignant glioma from 2007 to 2009.

Publication ,  Journal Article
Johnson, LA; Sampson, JH
Published in: Curr Neurol Neurosci Rep
July 2010

Malignant glioma is a deadly disease for which there have been few therapeutic advances over the past century. Although previous treatments were largely unsuccessful, glioma may be an ideal target for immune-based therapy. Recently, translational research led to several clinical trials based on tumor immunotherapy to treat patients with malignant glioma. Here we review 17 recent glioma immunotherapy clinical trials, published over the past 3 years. Various approaches were used, including passive transfer of naked and radiolabeled antibodies, tumor antigen-specific peptide immunization, and the use of patient tumor cells with or without dendritic cells as vaccines. We compare and discuss the current state of the art of clinical immunotherapy treatment, as well as its limited successes, pitfalls, and future potential.

Duke Scholars

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Published In

Curr Neurol Neurosci Rep

DOI

EISSN

1534-6293

Publication Date

July 2010

Volume

10

Issue

4

Start / End Page

259 / 266

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Neurology & Neurosurgery
  • Immunotherapy
  • Glioma
  • Clinical Trials as Topic
  • Brain Neoplasms
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
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Johnson, L. A., & Sampson, J. H. (2010). Immunotherapy approaches for malignant glioma from 2007 to 2009. Curr Neurol Neurosci Rep, 10(4), 259–266. https://doi.org/10.1007/s11910-010-0111-9
Johnson, Laura A., and John H. Sampson. “Immunotherapy approaches for malignant glioma from 2007 to 2009.Curr Neurol Neurosci Rep 10, no. 4 (July 2010): 259–66. https://doi.org/10.1007/s11910-010-0111-9.
Johnson LA, Sampson JH. Immunotherapy approaches for malignant glioma from 2007 to 2009. Curr Neurol Neurosci Rep. 2010 Jul;10(4):259–66.
Johnson, Laura A., and John H. Sampson. “Immunotherapy approaches for malignant glioma from 2007 to 2009.Curr Neurol Neurosci Rep, vol. 10, no. 4, July 2010, pp. 259–66. Pubmed, doi:10.1007/s11910-010-0111-9.
Johnson LA, Sampson JH. Immunotherapy approaches for malignant glioma from 2007 to 2009. Curr Neurol Neurosci Rep. 2010 Jul;10(4):259–266.
Journal cover image

Published In

Curr Neurol Neurosci Rep

DOI

EISSN

1534-6293

Publication Date

July 2010

Volume

10

Issue

4

Start / End Page

259 / 266

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Neurology & Neurosurgery
  • Immunotherapy
  • Glioma
  • Clinical Trials as Topic
  • Brain Neoplasms
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences