Clinical applications of a peptide-based vaccine for glioblastoma.

Published

Journal Article (Review)

Glioblastoma multiforme is a malignant, relentless brain cancer with no known cure, and standard therapies leave significant room for the development of better, more effective treatments. Immunotherapy is a promising approach to the treatment of solid tumors that directs the patient's own immune system to destroy tumor cells. The most successful immunologically based cancer therapy to date involves the passive administration of monoclonal antibodies, but significant antitumor responses have also been generated with active vaccination strategies and cell-transfer therapies. This article summarizes the important components of the immune system, discusses the specific difficulty of immunologic privilege in the central nervous system, and reviews treatment approaches that are being attempted, with an emphasis on active immunotherapy using peptide vaccines.

Full Text

Duke Authors

Cited Authors

  • Kanaly, CW; Ding, D; Heimberger, AB; Sampson, JH

Published Date

  • January 2010

Published In

Volume / Issue

  • 21 / 1

Start / End Page

  • 95 - 109

PubMed ID

  • 19944970

Pubmed Central ID

  • 19944970

Electronic International Standard Serial Number (EISSN)

  • 1558-1349

Digital Object Identifier (DOI)

  • 10.1016/j.nec.2009.09.001

Language

  • eng

Conference Location

  • United States