The role of tregs in glioma-mediated immunosuppression: potential target for intervention.

Journal Article (Journal Article;Review)

The role of regulatory T cells (Tregs) in mediating immune suppression of anti-tumor immune responses is increasingly appreciated in patients with malignancies-especially within the malignant glioma patient population. This article discuss the role and prognostic significance of Tregs within glioma patients and delineates potential approaches for their inhibition that can be used alone or in combination with other immune therapeutics in clinical trials and in the clinical settings of recurrent or residual disease.

Full Text

Duke Authors

Cited Authors

  • Humphries, W; Wei, J; Sampson, JH; Heimberger, AB

Published Date

  • January 2010

Published In

Volume / Issue

  • 21 / 1

Start / End Page

  • 125 - 137

PubMed ID

  • 19944972

Pubmed Central ID

  • PMC2786818

Electronic International Standard Serial Number (EISSN)

  • 1558-1349

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • United States